Condition

EGFR Activating Mutation clinical trials and research

• 9Clinical trials
• 1New in 30 days
• 4Countries

Newest EGFR Activating Mutation clinical trials

All recruiting trials (9)

• Osimertinib Plus SRS/SRT for EGFR-Mutant NSCLC with Symptomatic Brain Metastases

  This study tests whether adding targeted brain radiotherapy to osimertinib helps control brain metastases in adults with EGFR-mutant NSCLC and neurological symptoms.

  Recruiting Phase 2 Cho Ray Hospital · Ho Chi Minh City · NCT07911449

• EGFR-TKIs plus PD-1 antibody in first-line EGFR-mutant NSCLC

  This study tests whether adding a PD-1 antibody to a first-line EGFR-TKI helps people with EGFR-mutant advanced NSCLC see longer progression-free survival.

  Recruiting Phase 2 Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT07637448

• Pulsatile high-dose furmonertinib for EGFR-mutant NSCLC with leptomeningeal metastasis

  This tests whether taking high-dose furmonertinib every other day helps people with EGFR-mutant non-small cell lung cancer that has spread to the leptomeninges.

  Recruiting Guangzhou University of Traditional Chinese Medicine · Guangzhou, Guangdong · NCT07348965

• Combining osimertinib and dalpiciclib for advanced lung cancer after treatment resistance

  This study is testing if combining two drugs, osimertinib and dalpiciclib, can help people with advanced lung cancer who have not responded to other treatments.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT06363734

• Evaluating molecular factors and resistance mechanisms in lung cancer treatment

  This study is testing how well a specific lung cancer treatment works for patients with certain gene mutations and aims to find out why some patients might not respond to the treatment or have a relapse.

  Recruiting at 36 sites Intergroupe Francophone de Cancerologie Thoracique · Angers and 35 other locations · NCT06053099

• Evaluating TY-9591 for treating advanced lung cancer with brain metastases

  This study is testing a new drug called TY-9591 to see if it can help people with advanced lung cancer that has spread to the brain, compared to a standard treatment.

  Recruiting Phase 2 TYK Medicines, Inc · Beijing, Beijing Municipality · NCT05948813

• Comparing early and delayed brain radiotherapy with Almonertinib for lung cancer patients with brain metastases

  This study is testing whether giving brain radiotherapy right away or waiting a bit longer, along with a new lung cancer medication, helps people with brain metastases live longer and feel better.

  Recruiting Phase 3 Sun Yat-sen University · Guangdong, Guangzhou · NCT05768490

• Comparing TY-9591 and Osimertinib for advanced lung cancer

  This study is testing if a new drug called TY-9591 works better than the standard treatment Osimertinib for adults with advanced lung cancer that has specific genetic changes.

  Recruiting at 2 sites Phase 3 TYK Medicines, Inc · Changsha, Hunan and 1 other locations · NCT05382728

• Analyzing spinal fluid in lung cancer patients with leptomeningeal disease

  This study is trying to see how the spinal fluid and blood of lung cancer patients with a specific mutation differ, to better understand their condition and how it affects their quality of life.

  Recruiting British Columbia Cancer Agency · Vancouver, British Columbia · NCT05257967

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Quick answers

How many EGFR Activating Mutation clinical trials are recruiting right now?

9, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (6 trials), France (1 trial), Vietnam (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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