Condition

EGFR Gene Mutation clinical trials and research

• 12Clinical trials
• 15Countries

Newest EGFR Gene Mutation clinical trials

All recruiting trials (12)

• Sacituzumab tirumotecan plus furmonertinib for advanced EGFR‑mutant non‑squamous lung cancer after EGFR‑TKI and platinum chemotherapy

  This Phase II trial will test whether combining sacituzumab tirumotecan with furmonertinib helps people with advanced EGFR‑mutant non‑squamous NSCLC who progressed after EGFR‑TKI and platinum chemotherapy.

  Recruiting Phase 2 Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07548060

• Blood test for screening EGFR positive lung cancer in at-risk populations

  This study is testing a new blood test to see if it can help find EGFR positive lung cancer early in healthy people from East Asian and Latinx backgrounds who are at risk and can't have regular screenings.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts and 5 other locations · NCT06716580

• Combining nitroglycerin with radiation therapy for lung cancer patients with brain metastases

  This study is testing if adding nitroglycerin to radiation therapy can help lung cancer patients with brain metastases live longer and feel better.

  Recruiting Instituto Nacional de Cancerologia de Mexico · Mexico City, Mexico City · NCT06238882

• Using PET/CT to Measure HER3 Levels in Lung Cancer Patients

  This study is testing a new imaging method to see how much of a specific protein called HER3 is in lung cancer patients who have already been treated, to help figure out who might benefit from a new drug.

  Recruiting Phase 2 The Netherlands Cancer Institute · Amsterdam, North Holland · NCT06222489

• E-SYNC CAR T cell therapy for EGFRvIII positive glioblastoma

  This study is testing a new type of CAR T cell therapy to see if it can help people with a specific type of brain cancer called EGFRvIII positive glioblastoma after they have had chemotherapy.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT06186401

• Combining Nintedanib with EGFR inhibitors for advanced lung cancer

  This study is testing if combining a medication called Nintedanib with EGFR inhibitors can help people with advanced lung cancer who haven't responded to previous treatments.

  Recruiting Phase 1/2 China Medical University Hospital · Taichung · NCT06071013

• Understanding why some lung cancer patients don't respond to new treatments

  This study is trying to understand why some patients with advanced lung cancer don't respond to new treatments so that doctors can better tailor therapies to help them.

  Recruiting Second Xiangya Hospital of Central South University · Changsha, Hunan · NCT05598528

• Treatment for advanced lung cancer using furmonertinib and bevacizumab

  This study is testing a new combination of medications to see if it can help shrink tumors in patients with advanced lung cancer before surgery, making it easier to remove the cancer completely.

  Recruiting Phase 2 Shanghai Pulmonary Hospital, Shanghai, China · Shanghai, Shanghai Municipality · NCT05503667

• Evaluating Osimertinib with Early Stereotactic Radiosurgery for EGFR Mutated NSCLC with Brain Metastases

  This study is testing if combining a lung cancer drug called Osimertinib with early targeted radiation therapy can help people with EGFR-mutated non-small cell lung cancer and brain metastases live longer and maintain better brain function.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT05033691

• Treatment options for advanced lung cancer with specific genetic mutations

  This study is testing different targeted treatments for people with advanced lung cancer that have specific genetic mutations to see which ones can help them live longer and feel better.

  Recruiting Phase 2 Hunan Province Tumor Hospital · Changsha, Hunan · NCT04322890

• Treatment of advanced solid tumors with APL-101 for specific genetic mutations

  This study is testing a new oral medication called APL-101 to see if it helps people with advanced lung cancer and other solid tumors that have certain genetic changes, especially those who haven't had success with standard treatments.

  Recruiting at 32 sites Phase 2 Apollomics Inc. · Los Angeles, California and 34 other locations · NCT03175224

• Identifying tumor survival mechanisms in lung cancer after targeted therapy

  This study is trying to see how lung cancer tumors change before and after treatment with a specific drug to find ways to make the treatment work better.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT03042221

Related topics

Quick answers

How many EGFR Gene Mutation clinical trials are recruiting right now?

12, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 15 countries. The most sites are in United States (4 trials), China (4 trials), Taiwan (2 trials), Australia (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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