Using 18F-FES PET/CT imaging for breast cancer patients with brain metastases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study aims to optimize the use of 18F-FES PET/CT imaging in patients with estrogen receptor-positive breast cancer who have brain metastases. Participants will undergo standard MRI and FDG PET/CT scans for radiation treatment planning, along with an additional 18F-FES PET/CT scan to evaluate its effectiveness in differentiating brain metastases from radiation effects. The study will follow patients for 12 months, assessing clinical outcomes and survival metrics in relation to the imaging results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Active diagnosis of ER+ breast cancer (biopsy proven) and new or recurrent brain metastases (biopsy proven or suspected based on MRI appearance)
2. Ability to provide informed consent
3. Discontinuation of ER modulators for at least 8 weeks, and discontinuation of ER down regulators for at least 28 weeks (as per manufacturer guidelines)
4. Age \>=18 years
5. Eastern Cooperative Oncology Group performance score 0-1
6. Life expectancy \>=6 months
7. Planned for radiation treatment for brain metastases

Exclusion Criteria:

1. Pregnancy
2. Unable to undergo Standard of Care
3. Allergy to FES.

Where it's running

• New York-Presbyterian/Weill Cornell Medical Center
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Jana Ivanidze, MD/PhD — Weill Medical College of Cornell University
• Study coordinator: Jana Ivanidze, MD/PhD
• Email: jai9018@med.cornell.edu
• Phone: 212-746-4587

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.