Using a new imaging agent to detect lung cancer spread

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of fluorine-18-AlphaVBeta6-BP PET/CT imaging in detecting metastases in patients with Non-Small Cell Lung Cancer (NSCLC), particularly those with brain metastases. Participants will undergo this imaging technique alongside standard imaging methods to assess its sensitivity and specificity. The study aims to improve disease assessment and potentially enhance treatment planning for patients with metastatic NSCLC. Patients will be re-staged after 8-12 weeks to monitor changes in their condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Men and women age \>18 yrs
2. Biopsy proven NSCLC with brain metastases (treated or untreated)
3. Life-expectancy of ≥3 months in the opinion of the treating physician
4. Available archival tumor tissue (excisional, core, or fine needle aspiration (FNA) is acceptable). Tissue from a metastatic site is preferred when available.
5. Able to tolerate all study procedures, including remain motionless for up to 30-60 minutes per scan
6. Ability to understand and willingness to sign a written informed consent document.
7. Planned to undergo additional cancer-directed therapy followed by standard-of-care re-staging imaging
8. \[18F\]-FDG PET/CT within 21 days of enrollment
9. MRI brain within 21 days of enrollment
10. Eastern Cooperative Oncology Group Performance Status ≤ 2
11. Glomerular filtration rate (GFR) ≥ 60

Exclusion Criteria:

1. Pregnant or lactating women
2. Prisoners
3. Concurrent malignancy of a different histology that could confound imaging interpretation
4. Patients who cannot undergo PET/CT scanning because of weight limits(\>350lbs)

Where it's running

• The University of California Davis Comprehensive Cancer Center
  Sacramento, California, United States Recruiting

Study contacts

• Principal investigator: Julie L. Sutcliffe, PhD — The Regents of the University of California (Davis)
• Study coordinator: Principal Investigator
• Email: jlsutcliffe@ucdavis.edu
• Phone: 916-734-5536

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.