Neoadjuvant Stereotactic Radiotherapy for Brain Metastases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter proof-of-concept study evaluates the efficacy and safety of neoadjuvant stereotactic radiotherapy (NaSRT) for patients with brain metastases. The study aims to gather clinical data on local control, overall survival, and quality of life, while comparing outcomes with a retrospective control group. Patients will undergo MRI assessments and complete quality of life questionnaires to monitor their physical and psychological well-being. The goal is to establish NaSRT as a new treatment paradigm within the Czech neurooncology network.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Karnofsky Performance Status ≥ 60
* Histologically verified primary cancer disease
* MRI findings indicating BM
* Target BM indicated for surgical resection and any other metastases suitable for radical SRT.
* Target BM between 1 cm and 7 cm at the longest diameter on T1 post-contrast MR imaging

Exclusion Criteria:

* Confirmed hematological malignity
* Small-cell (lung) carcinoma
* Peracute condition requiring immediate neurosurgical intervention
* History of whole-brain radiotherapy (WBRT)
* History of stereotactic radiotherapy to a target brain metastasis
* Pregnancy
* Inability to perform surgical resection of the target BM within 7 days after NaSRT

Where it's running

• University Hospital Ostrava
  Ostrava, Moravian-Silesian Region, Czechia Recruiting
• Masaryk Memorial Cancer Institute
  Brno, Czechia Recruiting
• University Hospital Hradec Králové
  Hradec Králové, Czechia Recruiting
• University Hospital Olomouc
  Olomouc, Czechia Recruiting

Study contacts

• Principal investigator: Jakub Cvek, Assoc.Prof., MD, Ing, PhD, MBA — University Hospital Ostrava
• Study coordinator: Jiří Hynčica
• Email: jiri.hyncica@fno.cz
• Phone: 0042059737

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• EarlyFDG PET after Radiotherapy to See Brain Metastases and Radionecrosis

  This study tests whether a short FDG-PET scan after radiotherapy can help tell apart radionecrosis from recurring brain metastases in adults.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07632092

• IL-8 receptor–modified CAR T cells for brain metastases in adults

  This phase 1 study tests whether patient-derived, IL-8 receptor–modified CD70 CAR T cells can be safely given to adults with brain metastases.

  Recruiting Phase 1 University of Florida · Gainesville, Florida · NCT07569263

• Targeted FSRT plus bevacizumab versus hippocampus-sparing whole-brain radiation for people with lung adenocarcinoma that has spread to the brain

  This will test whether focused 5-day fractionated stereotactic radiotherapy (FSRT) combined with bevacizumab works better than hippocampus-avoidant whole-brain radiotherapy with a simultaneous boost at controlling brain metastases and protecting memory in adults with lung adenocarcinoma and extensive brain metastases.

  Recruiting at 3 sites Phase 3 Sun Yat-sen University · Chongqing, Chongqing Municipality and 2 other locations · NCT07481786

• Molecular comparison of primary gastroesophageal cancers and their brain metastases

  This project will test whether key biomarkers (HER2, MSI, PD-L1, CLDN18.2) match between primary gastroesophageal tumors and their matched brain metastases using archived tissue.

  Recruiting Blokhin's Russian Cancer Research Center · Moscow · NCT07464470

• Imaging inflammation in primary and metastatic brain tumors with [C-11]-CS1P1 PET

  This trial will test a new PET tracer, [C-11]-CS1P1, in adults with primary or secondary brain tumors to see if tracer patterns of inflammation relate to MRI, treatments, and clinical outcomes.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07462507

• Cognitive stepped care program for adults with brain metastases

  This project will test whether routine screening plus a stepped program of education and tailored cognitive support can help adults with brain metastases manage thinking and memory problems.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07355348

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.