Investigating how tumor-immune interactions affect brain metastases in triple-negative breast cancer.
Do Tumor-Immune Interactions Prime Systemic Tolerance of Triple-Negative Breast Cancer Brain Metastases?
This study is looking at how tumors and the immune system work together in women with triple-negative breast cancer that has spread to the brain, especially focusing on those of African ancestry, to find new ways to improve treatment and outcomes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10411906 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex interactions between tumors and the immune system in patients with triple-negative breast cancer (TNBC) that has spread to the brain. By employing a systems biology approach, the study aims to uncover the molecular mechanisms that drive metastasis and contribute to disparities in cancer outcomes, particularly among women of African ancestry. The research will analyze the immune environment in brain metastases to identify potential therapeutic targets and improve patient prognosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple-negative breast cancer, particularly those who have developed brain metastases.
Not a fit: Patients with other subtypes of breast cancer or those without brain metastases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against brain metastases in triple-negative breast cancer patients.
How similar studies have performed: Previous research has shown promise in understanding tumor-immune interactions in other cancer types, but this specific focus on TNBC brain metastases is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Umeh Garcia, Maxine Chidinma — Stanford University
- Study coordinator: Umeh Garcia, Maxine Chidinma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.