Understanding and disrupting the connection between cancer and the brain's immune system to prevent brain metastases.
Deconvolution and interruption of the cancer-neuro-immune axis facilitating brain metastases
This study is looking into how cancer spreads to the brain and aims to find better treatments for patients who are affected, so they can have improved survival and quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10977543 on NIH RePORTER |
What this research studies
This research focuses on the development of brain metastases, which affect up to 40% of cancer patients and significantly impact their survival and quality of life. The study aims to improve understanding and treatment of brain metastases by investigating the cancer-neuro-immune axis, which supports tumor growth in the brain. By utilizing human brain specimens and advanced technologies, the research seeks to identify key factors that facilitate brain metastasis and develop targeted therapies. Patients may benefit from new treatment strategies that could arise from this collaborative effort among brain and cancer experts.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are at risk of developing brain metastases.
Not a fit: Patients with cancers that do not metastasize to the brain may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve survival and quality of life for patients with brain metastases.
How similar studies have performed: Other research has shown promise in understanding cancer metastasis, but this specific approach to the cancer-neuro-immune axis is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Hayden Gephart, Melanie — Stanford University
- Study coordinator: Hayden Gephart, Melanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.