Effects of high protein diets on atherosclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of different types of high protein diets on atherosclerosis, a major contributor to cardiovascular diseases. Participants aged 45 to 75 with a body mass index between 25 and 40 will be assigned to consume standard meals, high animal protein meals, high plant protein meals, or high plant protein meals with added leucine. The research aims to understand how these dietary variations influence atherosclerotic plaque formation and characteristics. The findings could provide valuable insights into dietary recommendations for reducing cardiovascular disease risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \>=45 and \<=75 years of age
* body mass index \>=25.0 and \<40.0 kg/m2

Exclusion Criteria:

* \<45 and \>75 years of age
* body mass index \<25.0 or \>39.9 kg/m2
* plasma triglyceride \<125 mg/dl
* history of or current significant organ system dysfunction
* allergies or intolerances to meal ingredients
* use of medications or dietary supplements that could confound the study outcomes
* engaged in regular structured exercise \>150 min per week
* alcohol use disorder
* premenopausal women
* persons who smoke
* prisoners
* inability to grant voluntary informed consent

Where it's running

• University of Missouri School of Medicine
  Columbia, Missouri, United States Recruiting

Study contacts

• Principal investigator: Bettina Mittendorfer — University of Missouri-Columbia
• Study coordinator: Bettina Mittendorfer, PhD
• Email: b.mittendorfer@missouri.edu
• Phone: 6186103465

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.