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Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 and up

Comparing morning versus bedtime aspirin for cardiovascular health

Official title: Randomized Comparison of Morning Versus Bedtime Administration of Aspirin: A Cardiovascular Circadian Chronotherapy (C3) Trial

Run by Herlev and Gentofte Hospital · NCT05932472 · Data updated 2026-11-12

This study is testing if taking aspirin at bedtime works better than taking it in the morning for people who are already using aspirin to protect their heart health.

More Cardiovascular Diseases trials

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment32706 (estimated)
SponsorHerlev and Gentofte Hospital
Academic / other
Locations1 site (Hellerup)
StatusRecruiting
StartedJanuary 15, 2024
Main results expectedJanuary 15, 2027
Study endsFebruary 15, 2027
Registry record updatedFebruary 6, 2024
Trial IDNCT05932472 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who are currently on chronic aspirin treatment.

Probably not a fit

Patients who are not currently taking aspirin or those under 18 years old may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates whether taking aspirin at bedtime is more effective than taking it in the morning for reducing major adverse cardiovascular events in patients already on aspirin therapy. It utilizes a pragmatic, registry-based, open-label, randomized controlled design, leveraging Denmark's nationwide health registries for participant identification and data collection. Participants will provide electronic informed consent and will be randomized to either morning or bedtime aspirin administration without the need for in-person visits.

Why it matters

Potential benefit: If successful, this study could lead to improved cardiovascular outcomes for patients through optimized aspirin administration timing.

How similar studies have gone: Previous pilot studies have suggested potential benefits of bedtime aspirin administration, indicating a promising avenue for further investigation.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age \>=18 years
* Current chronic treatment with aspirin (as recorded in the Danish National Prescription Registry and confirmed by the participant via questionnaire)
* Signed informed consent

Exclusion Criteria:

* There are no exclusion criteria for this trial

Where it's running

  • Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte
    Hellerup, Denmark     Recruiting

Study contacts

  • Principal investigator: Manan Pareek, MD, PhD — Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte
  • Study coordinator: Niklas Dyrby Johansen, MD
  • Email: niklas.dyrby.johansen@regionh.dk
  • Phone: +4520204794

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.