Effects of diesel exhaust on inflammation and blood vessels
Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature
This study tests how breathing in diesel exhaust affects the blood vessels and inflammation in healthy people.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | University of Athens Academic / other |
| Locations | 2 sites (Athens, Attica and 1 other locations) |
| Trial ID | NCT04098536 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of diesel exhaust exposure on healthy individuals by conducting a cross-over double-blind design. Participants will be exposed to diesel fumes or filtered air for two hours, after which various cardiovascular parameters will be assessed, including endothelial function, arterial stiffness, and inflammatory markers. Measurements will be taken before exposure and at two and twenty-four hours post-exposure to evaluate the acute effects of diesel exhaust on vascular health.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy individuals without any chronic diseases.
Not a fit: Patients with chronic cardiovascular or respiratory diseases, as well as pregnant individuals, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the cardiovascular risks associated with diesel exhaust exposure, potentially leading to improved public health guidelines.
How similar studies have performed: Previous studies have indicated significant cardiovascular effects from diesel exhaust exposure, suggesting that this approach is supported by existing literature.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy subjects Exclusion Criteria: * Chronic diseases Cardiovascular diseases Respiratory diseases Pregnacy
Where this trial is running
Athens, Attica and 1 other locations
- 1st Cardiology Department, Hippokration General Hospital — Athens, Attica, Greece (Recruiting)
- Evangelos Oikonomou — Athens, Please Select, Greece (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.