Understanding sex hormones and inflammation in heart disease
Barts Sex-CAD Database: Do Female Sex Hormone Levels Inform Inflammatory Status and Susceptibility in Women Suffering Coronary Artery Disease?
Queen Mary University of London · NCT06327984
This study looks at how sex hormones and inflammation affect heart disease in women to better understand their unique risks and improve treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 6000 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | Queen Mary University of London (other) |
| Locations | 1 site (London) |
| Trial ID | NCT06327984 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the role of sex hormones and inflammatory markers in the progression of coronary artery disease (CAD), particularly in women. Researchers will collect data on hormone levels and various blood markers from patients admitted to Barts Heart Centre with chest pain. A questionnaire will also be administered to gather relevant medical history that may influence hormone status. The findings could help clarify the biological differences in CAD development between genders and improve patient care.
Who should consider this trial
Good fit: Ideal candidates include patients aged 16 and older presenting with chest pain at Barts Heart Centre.
Not a fit: Patients under 16 years old or those lacking the capacity to participate will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and treatment strategies for coronary artery disease in women.
How similar studies have performed: While there is limited research specifically addressing sex differences in CAD, studies exploring hormonal influences on cardiovascular health have shown promising insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria Any patient presenting with chest pain ≥16 years old presenting to Barts Heart Centre will be included. Exclusion criteria Patients \<16 years old and Adults lacking capacity will be excluded. Patients where the cause of their chest pain presentation is not related to coronary artery disease e.g musculoskeletal chest pain, aortic dissection, gastrointestinal, pulmonary embolism
Where this trial is running
London
- Barts Health NHS Trust — London, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Krishnaraj Rathod, MBBS PhD — Queen Mary University of London
- Study coordinator: Krishnaraj Rathod, MBBS PhD
- Email: k.s.rathod@qmul.ac.uk
- Phone: 020 7882 5720
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Artery Disease, Myocardial Infarction, Acute Coronary Syndrome, Atherosclerosis, Inflammation, Coronary artery disease, Acute coronary syndrome, Myocardial infarction