The Role of SECTM1 in Monocyte Biology and Atherosclerosis
Funded at Beth Israel Deaconess Medical Center · NIH-11399875 · Data updated 2026-11-12
A mentored career development program uses genetic and protein data to better understand how monocytes contribute to atherosclerosis, with findings tested in mouse models.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 9, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $164,484 |
| NIH project number | 5K08HL161445-05 |
| Project ID | NIH-11399875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with or at risk for cardiovascular disease who could benefit from advances in understanding immune cell roles in atherosclerosis.
✕Less likely to help
Patients without cardiovascular disease or those not connected to immune-related pathways may not directly benefit.
What this research studies
This grant supports a training-focused career development plan in functional genomics and systems biology, applying proteomics and human genetics to cardiovascular disease. The work aims to translate human data into mechanistic insights tested in small animal models of atherosclerosis. The mentor team includes experts in monocyte biology, murine atherosclerosis, and bioinformatics, guiding the applicant through computational and wet-lab approaches. The goal is to build skills that could ultimately help improve prevention or treatment strategies for patients with heart disease.
Why it matters
Potential benefit: If successful, the work could reveal new molecular players in atherosclerosis and point toward novel therapeutic targets.
How similar studies have gone: Previous studies have linked SECTM1 and monocyte biology to coronary risk, suggesting this approach could yield meaningful insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Tahir, Usman a. — Beth Israel Deaconess Medical Center
- Study coordinator: Tahir, Usman a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.