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Clinical trial Recruiting at 1 site Observational Ages 19 to 80

Effects of cannabis on blood vessels

Official title: Elucidating the Effects of Cannabis on Cardiovascular System

Run by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · NCT05581368 · Data updated 2026-11-12

This study looks at how using cannabis affects blood vessels and inflammation in people who regularly use it compared to those who don’t.

Quick facts

Study typeObservational
Ages19 Years to 80 Years
SexAll
Enrollment100 (estimated)
SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Academic / other
Locations1 site (London, Ontario)
StatusRecruiting
StartedDecember 1, 2023
Main results expectedJune 30, 2025
Study endsDecember 30, 2025
Registry record updatedJune 15, 2025
Trial IDNCT05581368 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals aged 19 to 80 who use cannabis at least 3-4 times per week and have no history of cardiovascular disease.

Probably not a fit

Patients who do not use cannabis or have a history of cardiovascular disease may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the impact of cannabis use on the cardiovascular system, particularly focusing on blood vessel function and inflammation levels. Participants will include chronic cannabis users and a control group of non-users, with assessments conducted through non-invasive vascular tests and blood sample analysis. The study seeks to clarify the long-term cardiovascular effects of cannabis, which remain unclear despite its widespread use. By comparing the two groups, the researchers hope to uncover potential adverse effects associated with cannabis consumption.

Why it matters

Potential benefit: If successful, this study could provide crucial insights into the cardiovascular risks associated with cannabis use, informing patients and healthcare providers.

How similar studies have gone: While there is limited research specifically on the long-term cardiovascular effects of cannabis, preliminary studies suggest potential risks, making this investigation both relevant and necessary.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* age: 19 to 80
* males and females
* all ethnicities
* cannabis use at least 3-4 times per week or more in the past 6 months (50 volunteers, experimental group)
* patients who do not use cannabis (50 volunteers, control group)
* no history of cardiovascular disease

Exclusion Criteria:

* that ingest cannabis containing cannabidiol (CBD)
* that are unable to provide a receipt for the cannabis product(s) they ingest
* that are unwilling to stop consuming soy products and/or genistein 48 hours prior to appointments.

Where it's running

  • London Regional Health Science Centre
    London, Ontario, Canada     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Cardiovascular Diseases 365Atherosclerosis 328London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's 77
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.