Condition

Hypercholesterolemia clinical trials and research

• 20Clinical trials
• 18NIH research projects
• 17Countries

Newest Hypercholesterolemia clinical trials

All recruiting trials (20)

• VERVE-102 for adults with or at high risk for heart disease

  This study tests whether VERVE-102 can lower bad cholesterol (LDL-C) compared with a placebo in adults with plaque buildup or high risk for it.

  Recruiting Phase 2 Verve Therapeutics, Inc. · DeSoto, Texas · NCT07839936

• Enlicitide (MK-0616) for adults with high cholesterol in India

  This study tests whether enlicitide helps lower bad cholesterol (LDL-C) compared with placebo in adults with hyperlipidemia/hypercholesterolemia.

  Recruiting at 2 sites Phase 3 Merck Sharp & Dohme LLC · Belagavi, Karnataka and 1 other locations · NCT07821944

• Pemafibrate in people with high cholesterol not fully controlled by statins

  This study tests whether taking Pemafibrate at 0.2 mg or 0.4 mg daily for 12 weeks helps people with high cholesterol who still don’t respond well to statins, compared with a placebo.

  Recruiting at 10 sites Phase 4 Kowa Company, Ltd. · Hokkaido and 9 other locations · NCT07634484

• Dual PCSK9 Inhibition in secondary prevention for high LDL-C with statin intolerance

  This study tests whether combining inclisiran and alirocumab lowers LDL cholesterol better than either drug alone in people with ASCVD who can’t tolerate statins.

  Recruiting Phase 4 University Medical Centre Ljubljana · Ljubljana · NCT07581808

• Moderate-Intensity Statin + Ezetimibe vs High-Intensity Statin in CKD with ASCVD

  In adults with chronic kidney disease and established cardiovascular disease, this study tests whether a moderate-intensity statin plus ezetimibe can match the benefits of a high-intensity statin alone over three years.

  Recruiting Yonsei University · Seoul · NCT07524101

• Corn oil versus avocado oil effects on cardiometabolic risk factors

  This trial will test whether following controlled diets containing either corn oil or avocado oil for 21 days changes cardiometabolic risk factors in adults with mildly to moderately high non‑HDL cholesterol.

  Recruiting Midwest Center for Metabolic and Cardiovascular Research · Addison, Illinois · NCT07514663

• Shr-1918 for high cholesterol not controlled on statins and PCSK9 inhibitors

  This study tests whether SHR-1918 can help people with hard-to-control high cholesterol who are already on statins and PCSK9 inhibitors.

  Recruiting Phase 2/3 Beijing Suncadia Pharmaceuticals Co., Ltd · Nanjing, Jiangsu · NCT07404553

• Bempedoic acid adherence, persistence, and effect in adults in Italy

  This project will see how well bempedoic acid works and how consistently adults with high cholesterol in Italy take it.

  Recruiting Federico II University · Naples, Napoli · NCT07374861

• Comparing two supplements (Cynacol vs Metacol) for lowering LDL cholesterol in mild high cholesterol

  This test will see if the supplement Cynacol lowers LDL cholesterol more than Metacol in adults aged 35–70 with mild high LDL (115–190 mg/dL).

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Lombardy · NCT07295327

• Fixed-dose pitavastatin plus ezetimibe for lowering cholesterol

  This will try a single pill combining pitavastatin and ezetimibe to lower cholesterol in adults who have been stable on atorvastatin or rosuvastatin.

  Recruiting Ahn-Gook Pharmaceuticals Co.,Ltd · Yongin-si · NCT07083206

• Registry for patients taking pitavastatin

  This study is collecting information from patients taking pitavastatin to see how well it works and how safe it is in everyday use for heart and cholesterol management.

  Recruiting Polish Mother Memorial Hospital Research Institute · Lodz · NCT06858982

• Using genetic testing to improve statin use in Veterans with high cholesterol

  This study is trying to see if genetic testing can help Veterans with high cholesterol better understand and stick to their statin medications to lower their risk of heart disease.

  Recruiting VA Office of Research and Development · Indianapolis, Indiana and 1 other locations · NCT06568601

• Evaluating HST101 for lowering cholesterol in Chinese patients

  This study is testing if a new drug called HST101 can lower cholesterol levels in Chinese patients who have high cholesterol and are at risk for heart disease.

  Recruiting at 17 sites Phase 3 Hasten Biopharmaceutical Co., Ltd. · Beijing, Beijing Municipality and 17 other locations · NCT06568471

• Cardiovascular risk assessment for patients with lipid disorders in emergency care

  This study is testing a new way to help emergency room patients with high cholesterol lower their heart disease risk by providing better care compared to the usual treatment.

  Recruiting Phase 2 Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06488105

• Testing a new gene editing treatment for patients with high cholesterol

  This study is testing a new gene editing treatment to see if it can safely lower cholesterol levels in people with high cholesterol that doesn't respond to other treatments.

  Recruiting at 18 sites Phase 1 Verve Therapeutics, Inc. · Garden Grove, California and 17 other locations · NCT06451770

• Evaluating how well patients in Italy stick to and benefit from Inclisiran treatment for high cholesterol

  This study looks at how well people in Italy stick to their Inclisiran treatment for high cholesterol and whether it helps them improve their health.

  Recruiting Federico II University · Naples · NCT06287177

• Evaluating the effectiveness of PCSK9 inhibitors for cholesterol management in Italy

  This study is testing how well people in Italy stick to using PCSK9 inhibitors like Repatha and Praluent to manage their cholesterol levels in everyday life.

  Recruiting at 26 sites Federico II University · Arzignano and 26 other locations · NCT05430828

• Guideline-based lipid lowering approach in Asia-Pacific patients

  This study tests if a special cholesterol management plan helps people in the hospital for a heart attack feel better compared to standard care.

  Recruiting at 11 sites Monash University · Wollongong, New South Wales and 21 other locations · NCT05325034

• Alirocumab for people on stable dialysis

  This study tests whether alirocumab can safely lower cholesterol in adults on stable hemodialysis or peritoneal dialysis over 12 weeks.

  Recruiting Phase 3 Baylor Research Institute · Dallas, Texas · NCT03480568

• Understanding the causes and progression of lipid disorders

  This study is trying to understand what causes lipid disorders, like high cholesterol, by looking at people's blood fat levels and genetics to improve how we diagnose and treat these conditions.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00353782

NIH-funded research (18)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Using behavioral nudges to improve family screening for inherited high cholesterol

  This project uses two patient-facing approaches based on behavioral economics to help people with familial hypercholesterolemia get their relatives screened for the condition.

  NIH research Northwestern University · Chicago, United States · NIH-11392680

• Improving Risk Stratification for Familial Hypercholesterolemia (FH)

  A patient-facing look at a study that aims to better predict who with familial hypercholesterolemia is at highest risk for early heart disease.

  NIH research Geisinger Clinic · Danville, United States · NIH-11379914

• Nonviral CRISPR-Cas9 delivery to liver cells to treat familial hypercholesterolemia

  A new approach uses nonviral methods to deliver CRISPR-Cas9 to liver cells and select edited cells with acetaminophen, aiming to permanently lower bad cholesterol in people with familial hypercholesterolemia.

  NIH research Clemson University · Clemson, United States · NIH-11370567

• Implementing multi-component approaches to help blood donors with familial hypercholesterolemia(

  A program to help people who donate blood and have familial hypercholesterolemia get the cholesterol-lowering treatment they need through a blood-donation center.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11324217

• Helping families find and treat inherited high cholesterol

  This project tests a clinic-based program to help primary care doctors find and treat children and adults with inherited high cholesterol (familial hypercholesterolemia).

  NIH research Geisinger Clinic · Danville, United States · NIH-11304545

• Familial hypercholesterolemia: closing gaps in prevention of heart disease

  A new NIH grant is exploring why people with familial hypercholesterolemia often go undiagnosed or receive uneven care, with the goal of improving early detection and prevention of heart disease.

  NIH research University of California-Irvine · Irvine, United States · NIH-11293026

• Better heart-risk prediction for inherited high cholesterol

  This project aims to give people with familial high cholesterol clearer, more personalized estimates of their future heart disease risk using genetic information, cholesterol measures, and other health factors.

  NIH research Geisinger Clinic · Danville, United States · NIH-11158873

• Finding family members at risk for inherited high cholesterol and Long QT heart rhythm problems

  This project compares contacting relatives directly versus asking patients to tell family members to find people at risk for familial hypercholesterolemia (FH) and Long QT syndrome (LQTS), focusing on Amish communities where two actionable genetic variants are common.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11097301

• Improving treatment for blood donors with high cholesterol

  This study is looking to make it easier for blood donors with Familial Hypercholesterolemia (FH) to get the cholesterol-lowering medications they need, by finding out what challenges they face and testing new ways to help them access treatment better.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11085084

• Fixing Genes for Familial High Cholesterol

  This project is developing new ways to fix the genes that cause a severe form of very high cholesterol called Familial Hypercholesterolemia.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11059209

• Gene Editing for Familial High Cholesterol

  This project explores a new way to use gene editing to help people with familial hypercholesterolemia, a condition causing very high cholesterol.

  NIH research Clemson University · Clemson, United States · NIH-11047691

• Improving diagnosis and care for familial hypercholesterolemia

  This study is working to make it easier for doctors to spot and treat familial hypercholesterolemia (FH), a genetic condition that causes high cholesterol and can lead to heart problems, so that both kids and adults can get the help they need earlier and stay healthier.

  NIH research Geisinger Clinic · Danville, United States · NIH-11043251

• How disturbed blood flow and high cholesterol affect artery cells

  This study is looking at how problems with blood flow and high cholesterol can lead to heart issues, using mice to learn more about how these factors affect tiny cells in our blood vessels, with the hope of finding new ways to prevent or treat atherosclerosis.

  NIH research Emory University · Atlanta, United States · NIH-10998460

• Investigating how cholesterol affects immune responses in artery disease

  This study is looking at how high cholesterol can cause inflammation in your arteries and lead to heart problems, and it’s testing whether blocking a specific pathway in your body can help prevent these issues, with the hope of finding better treatments for heart disease.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10988247

• Using nonviral methods to deliver CRISPR technology for treating high cholesterol

  This study is testing a new way to help people with familial hypercholesterolemia, a genetic condition that causes high cholesterol, by using a safe method to change liver cells and lower cholesterol levels, which could lead to better heart health.

  NIH research Clemson University · Clemson, United States · NIH-10882890

• Understanding and improving risk assessment in familial hypercholesterolemia

  This study is looking at familial hypercholesterolemia (FH), a genetic condition that causes high cholesterol and heart disease risk, to better understand its different types and how they affect heart health, so doctors can give clearer advice to patients from all backgrounds.

  NIH research Geisinger Clinic · Danville, United States · NIH-10872313

• How high cholesterol in pregnant women affects their children's liver health

  This study is looking at how high cholesterol in pregnant women might affect their children's liver health and is exploring safe plant-based ways to help lower cholesterol during pregnancy, so that kids can have a better chance of staying healthy.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-10808606

• Using mobile health technology to help teens with familial hypercholesterolemia take their statin medication

  This study is looking at how using mobile health apps can help teenagers with high cholesterol from their families remember to take their medication regularly, by finding fun and motivating ways to encourage them.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10685374

Related topics

Quick answers

How many Hypercholesterolemia clinical trials are recruiting right now?

20, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (7 trials), Italy (4 trials), South Korea (3 trials), China (3 trials), Australia (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 4: 2, Phase 2: 2, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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