Exercise training for patients with coronary artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial involves patients aged 40-70 with coronary artery disease (CAD) who will participate in a 12-week exercise training program, meeting three times a week. A control group of healthy individuals will also be included for comparison. Evaluations will occur at baseline and after the intervention, assessing carotid artery thickness and endothelial function, along with blood sample analysis for various metabolites and inflammatory markers. The study aims to understand the effects of exercise on cardiovascular health in CAD patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eligible CAD patients will be those aged 40 to 70 years, of both sexes, entering the cardiac rehabilitation program at HUPE. CAD will be defined as any acute coronary syndrome, including myocardial infarction with and without ST-segment elevation, and unstable angina (all defined by characteristic histories, electrocardiographic abnormalities, and cardiac enzyme abnormalities), or obstructive CAD diagnosed via coronary angiography (defined as ≥ 50% stenosis of any epicardial coronary artery) in patients with stable angina.
* Healthy controls: adults aged 40 to 70 years, of both sexes, without CAD evidence.

Exclusion Criteria:

* diagnosis of heart failure, pulmonary disease, Chagas disease, or tuberculosis
* regular physical exercise practice (≥ 3 days/week for 30 min) over the past 6 months
* malnutrition (body mass index \[BMI\] \< 18.5 kg/m²)
* smoking
* obesity (BMI ≥ 30 kg/m²)

Where it's running

• Rio de Janeiro State University
  Rio de Janeiro, Rio de Janeiro, Brazil Recruiting

Study contacts

• Principal investigator: Juliana Borges, PhD — Rio de Janeiro State University
• Study coordinator: Juliana Borges, PhD
• Email: juliana.borges@uerj.br
• Phone: +55212234

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.