Molecular imaging of artery disease in leg arteries
Official title: Molecular Imaging of Atherosclerosis in Peripheral Artery Disease
Funded at Research Inst Nationwide Children's Hosp · NIH-11404971 · Data updated 2026-11-12
A new imaging approach uses a special PET/CT scan to map blood flow and mineral buildup in leg arteries of people with PAD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | September 10, 2025 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $626,926 |
| NIH project number | 5R01HL173102-02 |
| Project ID | NIH-11404971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with lower-extremity PAD, including those with diabetes, who are candidates for non-invasive imaging to evaluate limb perfusion and vessel calcification.
✕Less likely to help
Patients without PAD or those unable to undergo PET/CT imaging would not benefit.
What this research studies
This project aims to create a patient-friendly imaging method that can measure how well blood reaches leg muscles and where artery calcification is happening. Researchers will use a dual-phase PET/CT with 18F-NaF to capture both perfusion and calcification in one session. The goal is to translate this technique to clinical care so doctors can better plan treatments for PAD patients, including those with diabetes who tend to have worse disease. Participants may undergo imaging and follow-up assessments to understand how the disease progresses and responds to interventions.
Why it matters
Potential benefit: If successful, patients could receive more precise imaging that helps tailor treatments and potentially prevent amputations.
How similar studies have gone: Previous work developed a dual-phase PET/CT approach showing promise in measuring perfusion and calcification.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Stacy, Mitchel R — Research Inst Nationwide Children's Hosp
- Study coordinator: Stacy, Mitchel R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.