Clinical trial Recruiting at 1 site Observational Ages 18 and up

Using blood biomarkers to assess heart disease risk

Official title: Biomarkers and Cardiac Computed Tomography: Relationship Between Cardiovascular Biomarkers and Coronary Artery Disease in Patients Undergoing Cardiac Computed Tomography

Run by Maastricht University Medical Center · NCT02381301 · Data updated 2026-11-12

This study is trying to see if certain blood markers can help identify people at risk for heart disease and serious heart problems when they have a routine heart scan.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment5000 (estimated)
SponsorMaastricht University Medical Center
Academic / other
Locations1 site (Maastricht, Limburg)
StatusRecruiting
StartedFebruary 2015
Main results expectedDecember 2029
Study endsDecember 2029
Registry record updatedMarch 28, 2017
Trial IDNCT02381301 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients referred from the cardiology clinic for routine coronary CT angiography.

Probably not a fit

Patients who are pregnant, have severe renal insufficiency, or have severe allergies to contrast medium may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between serum biomarkers and coronary artery disease (CAD) using multidetector computed tomography (CT). Patients referred for routine coronary CT angiography (CCTA) will have their venous blood sampled to identify potential biomarkers associated with atherothrombosis. The goal is to improve risk stratification for patients at risk of major adverse cardiac events (MACE) by utilizing these biomarkers. This approach could provide a cost-effective method for identifying individuals at higher risk for cardiovascular issues.

Why it matters

Potential benefit: If successful, this study could enhance early detection and risk assessment of coronary artery disease, leading to better patient outcomes.

How similar studies have gone: Other studies have shown promise in using biomarkers for cardiovascular risk assessment, indicating that this approach has potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients referred from the Cardiology clinic for routine CCTA.

Exclusion Criteria:

* Pregnancy
* Severe renal insufficiency
* Severe allergy to contrast medium
* Inability to obtain informed consent
* Age below 18 years

Where it's running

  • Maastricht University Medical Center
    Maastricht, Limburg, Netherlands
    Recruiting

Study contacts

  • Principal investigator: Bas Kietselaer, MD, PhD — Maastricht University Medical Center
  • Study coordinator: Bas Kietselaer, MD, PhD
  • Email: b.kietsealer@mumc.nl
  • Phone: +31433871587

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.