Using blood biomarkers to assess heart disease risk
Biomarkers and Cardiac Computed Tomography: Relationship Between Cardiovascular Biomarkers and Coronary Artery Disease in Patients Undergoing Cardiac Computed Tomography
This study is trying to see if certain blood markers can help identify people at risk for heart disease and serious heart problems when they have a routine heart scan.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Maastricht University Medical Center Academic / other |
| Locations | 1 site (Maastricht, Limburg) |
| Trial ID | NCT02381301 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between serum biomarkers and coronary artery disease (CAD) using multidetector computed tomography (CT). Patients referred for routine coronary CT angiography (CCTA) will have their venous blood sampled to identify potential biomarkers associated with atherothrombosis. The goal is to improve risk stratification for patients at risk of major adverse cardiac events (MACE) by utilizing these biomarkers. This approach could provide a cost-effective method for identifying individuals at higher risk for cardiovascular issues.
Who should consider this trial
Good fit: Ideal candidates for this study are patients referred from the cardiology clinic for routine coronary CT angiography.
Not a fit: Patients who are pregnant, have severe renal insufficiency, or have severe allergies to contrast medium may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance early detection and risk assessment of coronary artery disease, leading to better patient outcomes.
How similar studies have performed: Other studies have shown promise in using biomarkers for cardiovascular risk assessment, indicating that this approach has potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients referred from the Cardiology clinic for routine CCTA. Exclusion Criteria: * Pregnancy * Severe renal insufficiency * Severe allergy to contrast medium * Inability to obtain informed consent * Age below 18 years
Where this trial is running
Maastricht, Limburg
- Maastricht University Medical Center — Maastricht, Limburg, Netherlands (Recruiting)
Study contacts
- Principal investigator: Bas Kietselaer, MD, PhD — Maastricht University Medical Center
- Study coordinator: Bas Kietselaer, MD, PhD
- Email: b.kietsealer@mumc.nl
- Phone: +31433871587
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.