Condition

Heart Valve Diseases clinical trials and research

• 26Clinical trials
• 20Countries

Newest Heart Valve Diseases clinical trials

All recruiting trials (26)

• Transcatheter Tricuspid Valve Replacement for Severe Tricuspid Regurgitation

  This trial tests the Laplace TTVR System to see if it safely and effectively treats adults with severe tricuspid regurgitation.

  Recruiting at 2 sites Laplace Interventional, Inc · Tulsa, Oklahoma and 1 other locations · NCT07687485

• TRIFORMIS RESILIA heart valve real-world results in tricuspid disease

  A real-world, observational study to see how the Edwards TRIFORMIS RESILIA tricuspid heart valve performs in adults needing tricuspid valve replacement.

  Recruiting Edwards Lifesciences · Carmel, Indiana · NCT07684313

• Multimodal Cardiac MRI to See How the Heart Is Working

  This study tests a comprehensive MRI approach to characterize heart structure and tissue in adults with suspected or confirmed cardiovascular disease.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07617844

• Portable electronic stethoscope and machine-learning detection of heart valve disease

  We will test whether a portable electronic stethoscope combined with a machine-learning algorithm can accurately detect valvular heart disease in people with known valve problems and in healthy volunteers.

  Recruiting The University of Hong Kong · Hong Kong, Pok Fu Lam Rd. · NCT07568795

• Vyne TriNova Transcatheter Tricuspid Valve Replacement study for severe tricuspid regurgitation

  This trial tests the VDyne TriNova system in adults with symptomatic severe tricuspid regurgitation to see if it is safe and helps heart symptoms compared with an alternative device.

  Recruiting at 12 sites VDyne, Inc. · Phoenix, Arizona and 11 other locations · NCT07516444

• AI-assisted screening for heart valve disease using routine non-contrast chest CT

  This will test whether an AI program can spot moderate-to-severe heart valve disease on routine non-contrast chest CT scans in adults.

  Recruiting at 3 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Wuhan, Hubei and 2 other locations · NCT07449130

• Global longitudinal strain to predict difficult separation from cardiopulmonary bypass

  This will test whether a heart ultrasound measure called global longitudinal strain (GLS) can predict which adults having elective cardiac surgery will have trouble coming off cardiopulmonary bypass.

  Recruiting at 2 sites Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital · Rome and 1 other locations · NCT07390903

• Losartan after aortic valve replacement to help the heart recover

  This trial will try if taking losartan after aortic valve replacement helps the heart shrink back to a healthier size and improve recovery in adults who had severe aortic regurgitation.

  Recruiting Phase 4 University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07099859

• Korea VHD Echo Study: Real-World Practice of Aortic, Mitral, and Tricuspid Valves

  This study looks at how valvular heart disease is managed in Korea by reviewing echocardiograms and medical records from multiple centers to see patterns in disease progression and treatment.

  Recruiting at 2 sites Yonsei University · Seoul, Seoul and 1 other locations · NCT07068633

• Paired-Ring Mitral Annuloplasty Sizing Device for Mitral Valve Repair

  A pilot study tests a disposable sizing tool to help surgeons pick the final mitral ring size during repair in adults with heart valve disease.

  Recruiting Endeavor Health · Glenview, Illinois · NCT06965725

• Investigation of the EVOQUE System for Tricuspid Valve Replacement

  This study is testing a new device for replacing the tricuspid valve in people with heart valve problems to see how safe and effective it is.

  Recruiting at 21 sites Edwards Lifesciences · Bad Berka and 22 other locations · NCT06569602

• Evaluating a new device for replacing the tricuspid valve in patients with severe regurgitation

  This study is testing a new device to replace the tricuspid valve in adults with severe valve problems to see if it is safe and works well.

  Recruiting at 10 sites TRiCares · Atlanta, Georgia and 9 other locations · NCT06506942

• Using echocardiography to improve heart care in nursing homes

  This study tests if using echocardiograms in nursing homes can help improve heart care and reduce hospital visits for residents with heart disease.

  Recruiting Nantes University Hospital · Nantes, Loire-Atlantique · NCT06445231

• Investigating multiple and mixed heart valve diseases

  This study looks at how common different types of heart valve diseases are and their features by gathering information from patients around the world who have been diagnosed with these conditions.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06235385

• Reversing heparin with protamine after transfemoral TAVI

  This trial tries giving protamine to reverse heparin right after transfemoral TAVI in adults to see if it reduces bleeding and vascular complications.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06215378

• Measuring oxygen levels in the heart during open-heart surgery

  This study is testing a new device that measures oxygen levels in the heart during open-heart surgery to see how it affects recovery and heart function afterward.

  Recruiting Spectrocor · Helsinki, Uusimaa · NCT06084091

• Prognosis prediction for patients with cardiovascular and cerebrovascular diseases using multi-omics

  This study is trying to find out how different biological factors affect people with heart and brain blood vessel diseases to help doctors predict outcomes and personalize treatments for them.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi · NCT06001073

• Evaluating the DUO System for treating Tricuspid Regurgitation

  This study is testing a new heart valve system to see if it can help people with severe tricuspid regurgitation feel better and improve their heart function.

  Recruiting at 17 sites CroiValve Limited · Phoenix, Arizona and 17 other locations · NCT05913908

• Research on heart and kidney disease interactions

  This study looks at how heart and kidney problems affect each other to find better treatment options for people with cardiorenal syndrome.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing · NCT05397392

• Detecting heart valve disease and heart failure in a diverse community using cardiac ultrasound

  This study is testing if training primary care staff to use quick heart ultrasounds can help find heart valve disease and heart failure earlier in older people from different backgrounds.

  Recruiting Queen Mary University of London · London · NCT05208567

• Follow-up of patients treated with TricValve® for heart valve issues

  This study follows patients who have had treatment for severe tricuspid regurgitation using the TricValve® system to see how well the valve is working over the next five years.

  Recruiting at 12 sites P+F Products + Features GmbH · Sankt Pölten, Lower Austria and 27 other locations · NCT05114850

• New biological heart valves with an easy change system

  This study is testing new biological heart valves that are easier to replace to see how well they work and how they affect patients' health and quality of life after surgery.

  Recruiting Tomsk National Research Medical Center of the Russian Academy of Sciences · Tomsk, Tomsk Oblast · NCT04442100

• Observational registry for patients treated with the NeoChord Artificial Chordae System

  This study is looking at how well the NeoChord Artificial Chordae System works for people with degenerative mitral valve disease over five years, without needing any extra procedures beyond regular treatment.

  Recruiting at 5 sites NeoChord · Bonn and 4 other locations · NCT04190602

• Registry evaluating long-term outcomes of Transcatheter aortic valve replacement

  This study looks at how well Transcatheter Aortic Valve Replacement (TAVR) works for patients over time in real-life situations.

  Recruiting at 5 sites Asan Medical Center · Stanford, California and 6 other locations · NCT03826264

• Registry for transcatheter valve treatments in heart valve diseases

  This study looks at how safe and effective new heart valve treatments are for people with heart valve diseases to help improve their care and quality of life.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT03674788

• Using the Carillon Mitral Contour System to treat heart failure with mild functional mitral regurgitation

  This study is testing if the Carillon Mitral Contour System can help people with heart failure and mild mitral regurgitation feel better compared to a similar procedure without the device.

  Recruiting at 61 sites Cardiac Dimensions Pty Ltd · Gilbert, Arizona and 91 other locations · NCT03142152

Related topics

Quick answers

How many Heart Valve Diseases clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (8 trials), China (5 trials), France (4 trials), Germany (3 trials), Greece (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →