Evaluating treatments for severe aortic valve stenosis in elderly patients in Italy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to create a registry for elderly patients (aged 65 and older) with aortic valve stenosis who are eligible for valve replacement. It will assess various treatment options, including medical therapy, conventional surgery, and transcatheter aortic valve replacement (TAVR), to determine their advantages and limitations. The study is led by IRCCS Policlinico San Donato, which is responsible for cardiac valve pathologies, and seeks to enhance understanding of treatment outcomes beyond mere survival, focusing on quality of life. The registry will help inform future therapeutic strategies for this growing patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age higher or equal to 65 years;
* aortic valve stenosis that, according to current guidelines, should be treated by a valve replacement;
* written consent to participate.

Exclusion Criteria:

* aortic valve insufficiency not due to stenosis;
* refusal to participate.

Where it's running

• IRCCS Policlinico San Donato
  San Donato Milanese, Mi, Italy Recruiting

Study contacts

• Study coordinator: Marco Ranucci, MD
• Email: marco.ranucci@grupposandonato.it
• Phone: 0252774754

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Transcatheter Aortic Valve Replacement Registry for Outcomes and Quality Monitoring

  This registry collects information from hospitals about patients undergoing TAVR to see how care and outcomes compare to guidelines and nationwide data.

  Recruiting American College of Cardiology · Washington D.C., District of Columbia · NCT07908355

• Vericiguat to slow calcific aortic valve narrowing

  This trial tests whether vericiguat can slow the progression of mild-to-moderate calcific aortic valve stenosis compared with placebo.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT07715279

• CHATEAU Registry: Real-world outcomes after TAVR

  This registry collects real-world data from adults who had TAVR between 2021 and 2025 to see how they do over time and how valve performance holds up.

  Recruiting Eunpyeong St. Mary's Hospital · Seoul · NCT07709858

• Impact of TAVR on kidney function in people with aortic valve disease

  This registry tests how trans-catheter aortic valve implantation affects kidney function and the risk of kidney injury in adults with aortic stenosis.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT07626710

• Hydra THV Transfemoral Valve Implantation in Severe Aortic Stenosis

  This registry tests how safely and effectively the Hydra THV works when implanted through the femoral artery in adults with severe symptomatic aortic stenosis.

  Recruiting at 8 sites Fundación EPIC · Aravaca and 7 other locations · NCT07566624

• How the type of sedation affects recovery after TAVR

  This study will test whether three common sedation approaches (propofol, dexmedetomidine, or midazolam with fentanyl) change how people recover on the first day after transfemoral TAVR.

  Recruiting Phase 4 Endeavor Health · Glenview, Illinois · NCT07556523

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.