Investigating multiple and mixed heart valve diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the prevalence and characteristics of multiple and mixed valvular heart disease (MMVD) through a multicenter approach involving 174 centers across 35 countries. Patients diagnosed with MMVD via echocardiography will be recruited over a six-month period, with a one-year follow-up to assess clinical outcomes and management strategies. The study will evaluate various clinical, biological, and imaging characteristics, aiming to fill significant knowledge gaps regarding MMVD diagnosis and prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years
2. Patient referred to the cardiovascular imaging department.
3. Diagnosis of MMVD confirmed by transthoracic echocardiography, defined as:

   1. Multiple VHD: at least 2 moderates to severe VHD involving ≥ 2 different valves, using the current ESC guidelines.

      and/or
   2. Mixed VHD: at least moderate stenosis and at least moderate regurgitation of a single valve, using the current ESC guidelines.
4. Patient not refusing to have their data involved in the protocol after information.

Exclusion Criteria (patients fulfilling any of the following criteria are not eligible for inclusion in this study):

1. History of prior valve surgery or percutaneous valve intervention (concerning a valve other than those involved in the definition of MMVD).
2. Acute infective endocarditis at the time of evaluation for inclusion (confirmed according to modified Duke criteria) or history of endocarditis ≤ 6 months.
3. Complex congenital heart diseases.

Where it's running

• Assistance Publique Hôpitaux de Paris
  Paris, Île-de-France Region, France Recruiting

Study contacts

• Study coordinator: Théo PEZEL, MD PhD
• Email: theo.pezel@aphp.fr
• Phone: 668722489

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.