Using Enavogliflozin to Improve Outcomes After Aortic Valve Replacement

A Randomized, Double-Blind, Placebo-controlled Trial to Evaluate Efficacy and Safety of a Novel Sodium-Glucose Cotransporter 2 Inhibitor, Enavogliflozin Compared to Placebo on Reducing Major Cardiovascular Events or Worsening Heart Failure in Patients With Severe Aortic Stenosis Who Underwent Transcatheter Aortic Valve Replacement (TAVR) and With Heart Failure With Preserved Ejection Fraction (HFpEF)

This study is testing if a new heart medication called Enavogliflozin can help people who have had aortic valve replacement surgery avoid serious heart problems and improve their health.

Quick facts

• Phase: Phase 4
• Study type: Interventional
• Enrollment: 1040 (estimated)
• Ages: 19 Years and up
• Sex: All
• Sponsor: Asan Medical Center (Academic / other)
• Locations: 31 sites (Bucheon-si and 30 other locations)
• Trial ID: NCT05672836 on ClinicalTrials.gov

What this trial studies

This trial investigates the effectiveness of Enavogliflozin, a novel SGLT2 inhibitor, in reducing major cardiovascular and heart failure events in patients who have undergone transcatheter aortic valve replacement for severe aortic stenosis. Participants will receive either Enavogliflozin or a placebo, in addition to standard care, to assess its impact on their health outcomes. The study focuses on patients with heart failure with preserved ejection fraction, aiming to provide insights into the drug's potential benefits in this specific population.

Who should consider this trial

Good fit: Ideal candidates are patients aged 19 and older with symptomatic aortic stenosis who have successfully undergone transcatheter aortic valve replacement.

Not a fit: Patients who do not have heart failure or those who have not undergone successful transcatheter aortic valve replacement may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly reduce the risk of major cardiovascular events and hospitalizations for heart failure in patients after aortic valve replacement.

How similar studies have performed: Other studies have shown promising results with SGLT2 inhibitors in heart failure management, suggesting potential success for this approach.

Eligibility criteria

Inclusion Criteria:

1\. Patients aged ≥19 with symptomatic aortic stenosis who underwent successful transcatheter aortic valve replacement (TAVR)\* (either native valve or valve in valve with any approved/marketed device).

\* A successful TAVI is defined as device success according to the VARC-2(Valve Academic Research Consortium 2) and VARC-3 criteria:

1. correct positioning of a single prosthetic heart valve into the proper anatomical location AND
2. intended performance of the prosthetic heart valve (mean aortic valve gradient \<20 mmHg, peak velocity \<3 m/s, no moderate or severe prosthetic valve regurgitation) AND
3. absence of periprocedural complications (any type of stroke, life-threatening bleeding, acute coronary artery obstruction requiring intervention, major vascular complication requiring intervention, unresolved acute valve thrombosis, or any requirement of a repeat procedure).

2\. Heart Failure with Mildly Reduced or Preserved Ejection Fraction

1. Left ventricular ejection fraction (LVEF) ≥40%
2. structural heart disease\_Left ventricular hypertrophy (LVH) or Left atrial enlargement

   A. Left ventricular hypertrophy (LVH) with septal thickness or posterior wall thickness ≥ 1.1 cm or

   B. Left atrial (LA) enlargement with at least one of the following: LA width (diameter) ≥3.8 cm or LA length ≥ 5.0 cm, or LA area ≥ 20cm2, or LA volume ≥ 55mL or LA volume index ≥ 29mL/m.
3. NT-proBNP ≥ 300 pg/mL (for patients without ongoing atrial fibrillation) or NT-proBNP must be ≥ 600 pg/mL (for patients with ongoing atrial fibrillation).

3\. Patients who voluntarily participated in the written agreement

Exclusion Criteria:

1. Acute decompensated Heart Failure (exacerbation of chronic Heart Failure) requiring intravenous diuretics, vasodilators, inotropic agents, or mechanical support, or hemodynamic instability following the transcatheter aortic valve replacement procedure.
2. Currently receiving therapy with an SGLT2 inhibitor within 4 weeks prior to randomization; discontinuation of current use of SGLT2 inhibitor for the purposes of study enrolment is not permitted.
3. Known allergy, hypersensitivity, or previous intolerance to an SGLT2 inhibitors.
4. HF with reduced ejection fraction (LVEF \<40%).
5. Type 1 diabetes mellitus or diabetes ketoacidosis.
6. Chronic cystitis and/or recurrent urinary tract infection (≥2 times within 1 year).
7. Stroke or transient ischemic attack within 12 weeks prior to enrollment.
8. Symptomatic persistent hypotension and/or a systolic blood pressure (SBP) \< 95 mm Hg at screening or at randomization.
9. SBP ≥180 mmHg irrespective of treatment or SBP ≥160 mmHg with at least ≥3 antihypertensive drugs at screening or randomization.
10. Heart failure due to any of the following causes; known infiltrative cardiomyopathy (e.g. amyloid, sarcoid, lymphoma, endomyocardial fibrosis, haemochromatosis, Fabry disease), active myocarditis, constrictive pericarditis, cardiac tamponade, known hypertrophic obstructive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVD), or uncorrected primary valvular disease.
11. Severe renal insufficiency (eGFR \<30 ml/min/1.73 m2 of body-surface area based on the Modification of Diet in Renal Disease (MDRD) formula) or end-stage renal disease or requiring dialysis at the time of screening.
12. Acute or chronic liver disease with severe impairment of liver function (e.g., ascites, esophageal varices, coagulopathy) or serum levels of transminases or alkaline phosphatase more than two times the upper limit of normal at screening.
13. Chronic pulmonary disease requiring home oxygen, oral steroid therapy or hospitalization for exacerbation within 12 months, or significant chronic pulmonary disease in the Investigator's opinion, or primary pulmonary arterial hypertension.
14. Current or suspicious malignancy or history of malignancy within 5 years
15. Uncontrolled anaemia or haemoglobin \<9g/dl
16. Uncontrolled hypothyroidism or arrhythmia or tachycardia
17. Current ongoing alcoholic or drug addict
18. Subjects with non-cardiac co-morbidities with life expectancy less than 12 months
19. Planned major high-risk operation after transcatheter aortic valve replacement (TAVR)
20. Women of childbearing age who have not reached a consensus on the use of highly effective contraception. Pregnancy or breastfeeding.
21. Participation in other clinical trials, However, where at least one or more conditions are satisfied, it could be an exception according to an investigator's discretion;

    * Participating in the observational study expected no effect on the safety and/or effectiveness evaluation of this trial.
    * Screening failed before any interventional factor is involved.
    * Participants who have completed their involvement in clinical trials and have surpassed a 4-week period since their last administration of the investigational drug.
    * Participated in academic trials like strategic or medical device comparison studies conducted under standard therapy provided that there is no additional risk or a specific procedure to a subject and no interference between this trial and other studies.

Where this trial is running

Bucheon-si and 30 other locations

• Bucheon Sejong Hospital — Bucheon-si, South Korea (Recruiting)
• Gyeongsang National University Changwon Hospital — Changwon, South Korea (Recruiting)
• Daegu Catholic University Medical Center — Daegu, South Korea (Recruiting)
• Keimyung University Dongsan Medical Center — Daegu, South Korea (Recruiting)
• Kyungpook National University Hospital — Daegu, South Korea (Recruiting)
• Yeungnam University Medical Center — Daegu, South Korea (Not_yet_recruiting)
• Chungnam National University Hospital — Daejeon, South Korea (Recruiting)
• The Catholic University of Korea, Daejeon ST. Mary's Hospital — Daejeon, South Korea (Recruiting)
• Gangneung Asan Hospital — Gangneung, South Korea (Recruiting)
• Chonnam National University Hospital — Gwangju, South Korea (Recruiting)
• Inje University Ilsan Paik Hospital — Ilsan, South Korea (Recruiting)
• Gachon University Gil Hospital — Incheon, South Korea (Recruiting)
• Incheon Sejong Hospital — Incheon, South Korea (Recruiting)
• Inha University Hospital — Incheon, South Korea (Recruiting)
• The Catholic University of Korea, Incheon St. Mary's Hospital — Incheon, South Korea (Recruiting)
• Dong-A Medical Center — Pusan, South Korea (Recruiting)
• Inje University Pusan Paik Hospital — Pusan, South Korea (Recruiting)
• Pusan National University Hospital — Pusan, South Korea (Recruiting)
• Seoul university Bundang hospital — Seongnam-si, South Korea (Not_yet_recruiting)
• Asan Medical Center — Seoul, South Korea (Recruiting)
• Ewha Womans University Mokdong Hospital — Seoul, South Korea (Recruiting)
• Ewha Womans University Seoul Hospital — Seoul, South Korea (Recruiting)
• Hanyang University Seoul Hospital — Seoul, South Korea (Recruiting)
• Konkuk University Medical Center — Seoul, South Korea (Recruiting)
• Korea University Anam Hospital — Seoul, South Korea (Recruiting)
• Korea University Guro Hospital — Seoul, South Korea (Recruiting)
• SNU Boramae Medical Center — Seoul, South Korea (Recruiting)
• The Catholic Univ. of Korea Eunpyeong St. Mary's hospital — Seoul, South Korea (Recruiting)
• The Catholic University of Korea, ST. Vincent's Hospital — Suwon, South Korea (Recruiting)
• Uijeongbu Eulji Medical Center, Eulji University — Uijeongbu-si, South Korea (Not_yet_recruiting)
• Ulsan University Hospital — Ulsan, South Korea (Recruiting)

Study contacts

• Study coordinator: Jeong-youn Bae, Project manager

Conditions Aortic Valve Stenosis; Heart Failure; Transcatheter Aortic Valve Implantation; heart failure with preserved ejection fraction; Sodium-glucose cotransporter-2 inhibitor; transcatheter aortic valve replacement