Examining heart blood flow in patients with severe aortic valve narrowing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) with cardiac PET perfusion imaging in patients suffering from severe aortic valve stenosis. The study aims to understand how these measurements correlate with coronary artery disease, which is common in patients with aortic stenosis. By evaluating patients who are eligible for transcatheter aortic valve replacement, the study seeks to determine the effectiveness of FFR and iFR in assessing coronary flow reserve and guiding treatment decisions. The findings could help improve the management of patients with concurrent aortic stenosis and coronary artery disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients with severe aortic Stenosis eligible for transcatheter aortic stenosis
* left ventricular ejection fraction \> 55%
* no intolerance of Adenosin
* no history of bradycardia, atrioventricular Blockade
* intermediate coronary Stenosis with FFR\> 0.8
* Age \>65

Exclusion Criteria:

* intolerance of Adenosin
* left ventricular ejection fraction \< 55%

Where it's running

• Herz- und Diabeteszentrum, NRW
  Bad Oeynhausen, North Rhine-Westphalia, Germany Recruiting

Study contacts

• Principal investigator: Tanja Rudolph, MD — Consultant physician
• Study coordinator: Tanja Rudolph, MD
• Email: trudolph@hdz-nrw.de
• Phone: +495731971258

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.