How the type of sedation affects recovery after TAVR

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, Phase 4 trial enrolling adults scheduled for transfemoral TAVR under monitored anesthesia care who can consent in English or Spanish. Participants are randomly assigned to receive propofol, dexmedetomidine, or midazolam with fentanyl during the procedure. Researchers collect short patient-reported surveys on postoperative days 1 and 7 about pain, overall recovery experience, and satisfaction with anesthesia. The primary focus is differences in quality of recovery on the first day after the procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18-90 years old, inclusive
* Undergoing transfemoral TAVR under Monitored Anesthesia Care (MAC)
* Speaks English or Spanish
* Consents to participate

Exclusion Criteria:

* Preoperative heart rate \< 50 bpm or arrhythmias (e.g., AFib with RVR)
* Conduction abnormalities (e.g., 2nd/3rd degree AV block without pacer)
* Allergy or contraindication to study drugs
* Pulmonary artery pressure \> 70mmHg
* Morbid obesity BMI \> 50
* Pregnancy
* Unable to consent in English or Spanish

Where it's running

• Endeavor Health
  Glenview, Illinois, United States Recruiting

Study contacts

• Study coordinator: Jessica Brickner
• Email: jessica.brickner@endeavorhealth.org
• Phone: 847-570-1197

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• CHATEAU Registry: Real-world outcomes after TAVR

  This registry collects real-world data from adults who had TAVR between 2021 and 2025 to see how they do over time and how valve performance holds up.

  Recruiting Eunpyeong St. Mary's Hospital · Seoul · NCT07709858

• Using 4D Flow MRI to characterize left ventricular failure

  This project will test whether automated 4D Flow MRI analysis can measure left ventricular dysfunction in adults with severe aortic stenosis who are scheduled for TAVR.

  Recruiting at 2 sites IRCCS Policlinico S. Donato · San Donato Milanese and 1 other locations · NCT07455292

• Tracking progression and consequences of heart valve disease

  This project will follow adults with moderate or worse valve disease to see if clinical tests and imaging can predict when their condition will get worse.

  Recruiting at 15 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Fuzhou, Fujian and 14 other locations · NCT07267117

• Using Ticagrelor or Aspirin for Patients After Aortic Valve Implantation

  This study tests whether Ticagrelor works better than Aspirin to prevent blood clots and complications in adults with severe aortic stenosis after they have a heart valve replacement.

  Recruiting Phase 4 Fundacin Biomedica Galicia Sur · Vigo, Pontevedra · NCT05283356

• Transcatheter Aortic Valve Replacement Registry for Outcomes and Quality Monitoring

  This registry collects information from hospitals about patients undergoing TAVR to see how care and outcomes compare to guidelines and nationwide data.

  Recruiting American College of Cardiology · Washington D.C., District of Columbia · NCT07908355

• Vericiguat to slow calcific aortic valve narrowing

  This trial tests whether vericiguat can slow the progression of mild-to-moderate calcific aortic valve stenosis compared with placebo.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT07715279

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.