Condition

Mitral Valve Disease clinical trials and research

• 18Clinical trials
• 3NIH research projects
• 18Countries

Newest Mitral Valve Disease clinical trials

All recruiting trials (18)

• MRace Implant: A first look at fixing the mitral valve to reduce regurgitation

  This single-arm study tests whether the MRace Implant and Delivery System can safely place a prosthesis to reduce severe mitral regurgitation in high-risk patients who may not be good candidates for open-heart surgery.

  Recruiting at 4 sites Polares Medical SA · Tbilisi and 3 other locations · NCT07796659

• Mitral Valve Calcification Imaging with TrueVue 3D Light Rendering

  This study tests how well three-dimensional transesophageal echocardiography with TrueVue transillumination detects mitral valve calcifications compared with CT in adults.

  Recruiting Centro Cardiologico Monzino · Milan, Milan · NCT07612553

• Tracking progression and consequences of heart valve disease

  This project will follow adults with moderate or worse valve disease to see if clinical tests and imaging can predict when their condition will get worse.

  Recruiting at 15 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Fuzhou, Fujian and 14 other locations · NCT07267117

• Surgical implantation of a polymer prosthetic mitral or aortic valve

  This will test a surgically implanted polymer heart valve to see if it is safe and works well for adults who need mitral or aortic valve replacement.

  Recruiting Mitrassist Lifesciences Limited Co., Ltd. · Shanghai, Shanghai Municipality · NCT07097740

• Abbott Cephea registry for mitral valve disease

  Collects clinical information on adults with symptomatic mitral valve disease to see how correcting the valve with the Cephea system affects outcomes for patients who might be candidates for transcatheter mitral valve replacement.

  Recruiting at 24 sites Abbott Medical Devices · Birmingham, Alabama and 23 other locations · NCT07069673

• Using the CoolCryo System to treat Atrial Fibrillation during Mitral Valve Surgery

  This study is testing whether the CoolCryo system can safely help people with atrial fibrillation feel better during mitral valve surgery.

  Recruiting at 2 sites Medinice S.A. · Bydgoszcz and 1 other locations · NCT06557616

• Left atrial shunt to help after mitral valve surgery

  This study tests whether making a small opening between the left and right atria during mitral valve repair can relieve high left atrial pressure for adults with primary mitral regurgitation.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06547788

• Investigating multiple and mixed heart valve diseases

  This study looks at how common different types of heart valve diseases are and their features by gathering information from patients around the world who have been diagnosed with these conditions.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06235385

• Evaluating the elasticity of the mitral valve in living humans

  This study is trying to see how stretchy the mitral valve chords are in people who need mitral valve replacement, comparing those with mitral valve prolapse to those with a different heart condition.

  Recruiting Centre Hospitalier Universitaire de Saint Etienne · Saint-Etienne · NCT06153563

• MRace Posterior Leaflet Repair for Severe Mitral Regurgitation

  This early feasibility study tests the MRace Implant and Delivery System to see if it can safely reduce severe mitral regurgitation in high-risk patients who are not good candidates for traditional surgery.

  Recruiting at 2 sites Polares Medical SA · Porto Alegre, Rio Grande do Sul and 1 other locations · NCT06113354

• Using UniLine Bioprosthesis for Aortic and Mitral Valve Diseases

  This study is testing how well the UniLine bioprosthesis works for people with aortic and mitral valve diseases over the long term, including any problems that might come up after the replacement.

  Recruiting Closed Joint-Stock Company NeoCor · Kemerovo, Kemerovo Oblast · NCT06025149

• Evaluating transcatheter mitral valve interventions in Chinese patients with mitral valve disease

  This study is testing how safe and effective new procedures for fixing or replacing the mitral valve are for Chinese patients with mitral valve disease.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04954404

• Registry for patients undergoing transcatheter mitral valve replacement

  This study is tracking patients with serious mitral valve problems who are getting a new type of heart valve through a less invasive procedure to see how well it works and how long it lasts.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT04914468

• Survey of patients who fail screening for mitral valve interventions

  This study is trying to learn more about patients who aren't eligible for a specific heart valve procedure to help improve future treatments for mitral valve disease.

  Recruiting at 16 sites Medstar Health Research Institute · Phoenix, Arizona and 15 other locations · NCT04736667

• Registry for optimal treatment options for mitral valve issues

  This study looks at how well different treatments work for people with serious mitral valve problems, comparing those who had a new valve implanted to those who weren't able to get that treatment.

  Recruiting at 43 sites Universitätsklinikum Hamburg-Eppendorf · Tucson, Arizona and 42 other locations · NCT04688190

• MITRAL II Pivotal: Transcatheter mitral valve replacement for severe mitral annular calcification

  This trial tests whether placing an Edwards SAPIEN transcatheter valve through a transseptal approach helps high-surgical-risk adults with severe mitral annular calcification and symptomatic mitral valve dysfunction.

  Recruiting at 14 sites Mayo Clinic · Gilbert, Arizona and 16 other locations · NCT04408430

• Observational registry for patients treated with the NeoChord Artificial Chordae System

  This study is looking at how well the NeoChord Artificial Chordae System works for people with degenerative mitral valve disease over five years, without needing any extra procedures beyond regular treatment.

  Recruiting at 5 sites NeoChord · Bonn and 4 other locations · NCT04190602

• Registry for patients with severe mitral valve disease not suitable for surgery

  This study is creating a registry to track the health and treatment of French patients with severe mitral valve disease who can't have surgery, to see how they do over the next two years.

  Recruiting at 3 sites French Cardiology Society · Lyon and 2 other locations · NCT02925819

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding mitral valve disease at the single-cell level

  A patient-centered study will map the cells and molecular patterns in mitral valve disease to understand why MVP develops and how it progresses.

  NIH research Yale University · New Haven, United States · NIH-11345855

• Understanding Mitral Valve Disease at a Molecular Level

  This research aims to understand the tiny molecular details of mitral valve prolapse, a condition where heart valve leaflets thicken, by looking closely at patient samples.

  NIH research Yale University · New Haven, United States · NIH-11173572

• Understanding the molecular details of mitral valve disease

  This study is looking at mitral valve prolapse (MVP) by exploring the tiny building blocks of the heart's mitral valve in both MVP patients and healthy people, to better understand what causes the condition and how it develops.

  NIH research Yale University · New Haven, United States · NIH-10858142

Related topics

Quick answers

How many Mitral Valve Disease clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in France (4 trials), United States (4 trials), Germany (3 trials), Canada (3 trials), China (3 trials). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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