Understanding how genetic factors influence aortic valve disease progression
Official title: Defining Epigenetic Regulation of Translational and Post-Translational Modification Signaling in Aortic Valve Stenosis via Multi-Omics Approaches
Funded at Brigham and Women's Hospital · NIH-10947414 · Data updated 2026-11-12
This study is looking at the genes and molecules involved in calcific aortic valve disease (CAVD) to find new ways to treat it, which could help patients who currently have few options and often need surgery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $114,938 |
| NIH project number | 1K99HL175119-01 |
| Project ID | NIH-10947414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over the age of 75 who are experiencing symptoms of calcific aortic valve disease.
✕Less likely to help
Patients with aortic valve disease who are not experiencing significant symptoms or who are not yet diagnosed may not benefit from this research.
What this research studies
This research investigates the genetic and molecular mechanisms that contribute to calcific aortic valve disease (CAVD), a condition that can lead to serious heart problems. By using advanced multi-omics approaches, the study aims to identify specific proteins and epigenetic factors that play a role in the disease's progression. Patients with CAVD currently have limited treatment options and often must wait for surgery, so this research seeks to uncover new therapeutic targets that could lead to better management of the disease. The findings may help in developing new strategies to prevent or treat CAVD more effectively.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of aortic valve disease, improving patient outcomes.
How similar studies have gone: Other research has shown promise in exploring genetic and epigenetic factors in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Clift, Cassandra Lucille — Brigham and Women's Hospital
- Study coordinator: Clift, Cassandra Lucille
Related research
Other NIH-funded projects on the same topics.
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Metformin Readiness for Aortic Valve Stenosis
A plan to prepare for a patient-focused trial of metformin to slow aortic valve stenosis in adults, using insights from human valves and biology.
-
Understanding how immune cells affect aortic valve disease differently in men and women
This study is looking at how men and women experience heart valve problems caused by aortic valve stenosis, focusing on the role of immune cells and inflammation, to find new treatments that could work better for each sex.
-
Transcatheter Aortic Valve Replacement Registry for Outcomes and Quality Monitoring
This registry collects information from hospitals about patients undergoing TAVR to see how care and outcomes compare to guidelines and nationwide data.
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Vericiguat to slow calcific aortic valve narrowing
This trial tests whether vericiguat can slow the progression of mild-to-moderate calcific aortic valve stenosis compared with placebo.
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CHATEAU Registry: Real-world outcomes after TAVR
This registry collects real-world data from adults who had TAVR between 2021 and 2025 to see how they do over time and how valve performance holds up.
-
Impact of TAVR on kidney function in people with aortic valve disease
This registry tests how trans-catheter aortic valve implantation affects kidney function and the risk of kidney injury in adults with aortic stenosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.