Understanding how genetic factors influence aortic valve disease progression
Defining Epigenetic Regulation of Translational and Post-Translational Modification Signaling in Aortic Valve Stenosis via Multi-Omics Approaches
['FUNDING_CAREER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10947414
This study is looking at the genes and molecules involved in calcific aortic valve disease (CAVD) to find new ways to treat it, which could help patients who currently have few options and often need surgery.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10947414 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and molecular mechanisms that contribute to calcific aortic valve disease (CAVD), a condition that can lead to serious heart problems. By using advanced multi-omics approaches, the study aims to identify specific proteins and epigenetic factors that play a role in the disease's progression. Patients with CAVD currently have limited treatment options and often must wait for surgery, so this research seeks to uncover new therapeutic targets that could lead to better management of the disease. The findings may help in developing new strategies to prevent or treat CAVD more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over the age of 75 who are experiencing symptoms of calcific aortic valve disease.
Not a fit: Patients with aortic valve disease who are not experiencing significant symptoms or who are not yet diagnosed may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of aortic valve disease, improving patient outcomes.
How similar studies have performed: Other research has shown promise in exploring genetic and epigenetic factors in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CLIFT, CASSANDRA LUCILLE — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: CLIFT, CASSANDRA LUCILLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aortic valvular disorders