Understanding how immune cells affect aortic valve disease differently in men and women
Identifying the Role of Fibroblast-Macrophage Crosstalk in Aortic Valve Stenosis Sexual Dimorphism
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF COLORADO · NIH-10998691
This study is looking at how men and women experience heart valve problems caused by aortic valve stenosis, focusing on the role of immune cells and inflammation, to find new treatments that could work better for each sex.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO (nih funded) |
| Locations | 1 site (Boulder, UNITED STATES) |
| Trial ID | NIH-10998691 on ClinicalTrials.gov |
What this research studies
This research investigates the differences in how men and women experience aortic valve stenosis (AVS), a condition that leads to heart valve problems. It focuses on the role of immune cells, particularly macrophages, in the progression of AVS and how these processes differ between sexes. By examining the inflammatory responses and cellular interactions in the heart valves, the study aims to uncover potential new treatments that could be tailored based on a patient's sex and inflammatory status. Patients may be involved in providing samples or data that help researchers understand these mechanisms better.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old, particularly those diagnosed with aortic valve stenosis.
Not a fit: Patients with aortic valve stenosis who are under 21 years old or do not have the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment options for aortic valve stenosis that consider sex differences in disease progression.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in cardiovascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Boulder, UNITED STATES
- UNIVERSITY OF COLORADO — Boulder, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHANG, ALEX — UNIVERSITY OF COLORADO
- Study coordinator: KHANG, ALEX
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.