Metformin Readiness for Aortic Valve Stenosis
Official title: Trial Readiness for Metformin in Aortic Valve Stenosis
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11441442 · Data updated 2026-11-12
A plan to prepare for a patient-focused trial of metformin to slow aortic valve stenosis in adults, using insights from human valves and biology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | August 10, 2026 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $744,613 |
| NIH project number | 1R34HL188688-01 |
| Project ID | NIH-11441442 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with tricuspid aortic valve stenosis who are receiving usual care and meet imaging and feasibility criteria for a trial-ready framework.
✕Less likely to help
Patients not fitting the eligibility criteria or those not proceeding to a trial-focused pathway may not directly benefit from this preparatory work.
What this research studies
This project aims to translate exciting lab and patient data into a trial-ready framework for metformin in adults with aortic valve stenosis. It will observe patients under usual care to define who could be eligible, how many could enroll, and how the disease progresses with standardized heart imaging. The study teams will finalize procedures, train sonographers and readers, and set up reliable measurements that could support a future interventional trial. By focusing on real-world patients and rigorous imaging readouts, the work seeks to lay the groundwork for a potential disease-modifying treatment path.
Why it matters
Potential benefit: If successful, this work could pave the way for a future treatment option that slows valve disease progression and improves heart health.
How similar studies have gone: Previous findings in humans and animals support a plausible link between the pathway targeted by metformin and valve biology, with early signals suggesting potential benefit.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Trivedi, Chinmay M — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Trivedi, Chinmay M
Related research
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Understanding how immune cells affect aortic valve disease differently in men and women
This study is looking at how men and women experience heart valve problems caused by aortic valve stenosis, focusing on the role of immune cells and inflammation, to find new treatments that could work better for each sex.
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This study is looking at the genes and molecules involved in calcific aortic valve disease (CAVD) to find new ways to treat it, which could help patients who currently have few options and often need surgery.
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Transcatheter Aortic Valve Replacement Registry for Outcomes and Quality Monitoring
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Vericiguat to slow calcific aortic valve narrowing
This trial tests whether vericiguat can slow the progression of mild-to-moderate calcific aortic valve stenosis compared with placebo.
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CHATEAU Registry: Real-world outcomes after TAVR
This registry collects real-world data from adults who had TAVR between 2021 and 2025 to see how they do over time and how valve performance holds up.
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Impact of TAVR on kidney function in people with aortic valve disease
This registry tests how trans-catheter aortic valve implantation affects kidney function and the risk of kidney injury in adults with aortic stenosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.