Clinical trial Recruiting at 2 sites Observational Ages 19 and up

Biobank for studying genetic factors in aortic stenosis and cardiovascular diseases

Official title: Translational-Omics in Aortic Stenosis (TOmAS) Biobank

Run by McGill University Health Centre/Research Institute of the McGill University Health Centre · NCT05930899 · Data updated 2026-11-12

This study is collecting samples and health information from people with aortic stenosis and other heart diseases to see if they can find new genetic clues that could improve diagnosis and treatment.

Quick facts

Study typeObservational
Ages19 Years and up
SexAll
Enrollment10000 (estimated)
SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre
Academic / other
Locations2 sites (Montreal, Quebec and 1 other locations)
StatusRecruiting
StartedOctober 12, 2017
Main results expectedJanuary 1, 2040
Study endsJanuary 1, 2040
Registry record updatedNovember 20, 2024
Trial IDNCT05930899 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals diagnosed with cardiovascular diseases who are undergoing cardiac surgery for non-aortic valve issues.

Probably not a fit

Patients with congenital heart disease will not benefit from this study as they are excluded from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The TOmAS Biobank aims to collect and preserve biological materials, genetic material, and clinical data from patients with cardiovascular diseases, particularly aortic stenosis, as well as control participants. This observational study will facilitate future research into novel biomarkers using proteomic, transcriptomic, and epigenomic technologies. By analyzing these samples, researchers hope to uncover new insights into the genetic and physiological factors contributing to cardiovascular diseases, ultimately enhancing diagnosis and treatment options. The biobank will serve as a valuable resource for ongoing and future studies in this field.

Why it matters

Potential benefit: If successful, this research could lead to the identification of new biomarkers that improve the prevention and treatment of cardiovascular diseases.

How similar studies have gone: Other studies utilizing biobanks and -omic technologies have shown promise in identifying biomarkers for cardiovascular diseases, suggesting a potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* CVD diagnosis including, but not limited to: Aortic Stenosis, Coronary Heart Disease, Heart Failure, Atrial Fibrilation, Dilated Cardiomyopathy, Myocardial Infarction, and Spontaneous Coronary Artery Dissection.
* Undergoing cardiac surgery for non-aortic valve pathology

Exclusion Criteria:

* Individuals with Congenital heart disease will be excluded

Where it's running

  • Montreal General Hospital
    Montreal, Quebec, Canada
    Recruiting
  • Royal Victoria Hospital
    Montreal, Quebec, Canada
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.