Biobank for studying genetic factors in aortic stenosis and cardiovascular diseases
Official title: Translational-Omics in Aortic Stenosis (TOmAS) Biobank
Run by McGill University Health Centre/Research Institute of the McGill University Health Centre · NCT05930899 · Data updated 2026-11-12
This study is collecting samples and health information from people with aortic stenosis and other heart diseases to see if they can find new genetic clues that could improve diagnosis and treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre Academic / other |
| Locations | 2 sites (Montreal, Quebec and 1 other locations) |
| Status | Recruiting |
| Started | October 12, 2017 |
| Main results expected | January 1, 2040 |
| Study ends | January 1, 2040 |
| Registry record updated | November 20, 2024 |
| Trial ID | NCT05930899 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with cardiovascular diseases who are undergoing cardiac surgery for non-aortic valve issues.
✕Probably not a fit
Patients with congenital heart disease will not benefit from this study as they are excluded from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The TOmAS Biobank aims to collect and preserve biological materials, genetic material, and clinical data from patients with cardiovascular diseases, particularly aortic stenosis, as well as control participants. This observational study will facilitate future research into novel biomarkers using proteomic, transcriptomic, and epigenomic technologies. By analyzing these samples, researchers hope to uncover new insights into the genetic and physiological factors contributing to cardiovascular diseases, ultimately enhancing diagnosis and treatment options. The biobank will serve as a valuable resource for ongoing and future studies in this field.
Why it matters
Potential benefit: If successful, this research could lead to the identification of new biomarkers that improve the prevention and treatment of cardiovascular diseases.
How similar studies have gone: Other studies utilizing biobanks and -omic technologies have shown promise in identifying biomarkers for cardiovascular diseases, suggesting a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * CVD diagnosis including, but not limited to: Aortic Stenosis, Coronary Heart Disease, Heart Failure, Atrial Fibrilation, Dilated Cardiomyopathy, Myocardial Infarction, and Spontaneous Coronary Artery Dissection. * Undergoing cardiac surgery for non-aortic valve pathology Exclusion Criteria: * Individuals with Congenital heart disease will be excluded
Where it's running
-
Montreal General Hospital
Montreal, Quebec, Canada Recruiting -
Royal Victoria Hospital
Montreal, Quebec, Canada Recruiting
Study contacts
- Study coordinator: George Thanassoulis, MD
- Email: george.thanassoulis@mcgill.ca
- Phone: 5149341934
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.