TAVI-in-TAVI with Myval: following patients who had a prior TAVI to see how they do over time

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects data from patients undergoing TAVI-in-TAVI with the Myval valve across several European centers. It relies on information from routine medical care, including prior conditions, the procedure details, complications, hospital stays, and routinely performed imaging. The goal is to understand real-world outcomes and long-term follow-up after a second catheter-based valve in a previously implanted valve. Imaging assessments such as echocardiography or CT may be evaluated if performed as part of standard care. Follow-up is planned for up to five years.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A TAVI-in-TAVI procedure with implantation of the Myval THV (Oc-taCor/OctaPRO) into a previously implanted (≥3 months) failing transcatheter heart valve of any kind is either planned, has al-ready been performed, or was attempted, based on a clinical indi-cation established by the treating heart team.
* Age: 18 years or more
* Informed consent has been obtained.

Exclusion Criteria:

* Participation in an interventional clinical trial
* Limited life expectancy \<12 months
* Foreseeable problems in performing follow-up visits

Where it's running

• Universitätsklinikum Freiburg/Bad Krozingen
  Freiburg im Breisgau, Germany Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Transcatheter Aortic Valve Replacement Registry for Outcomes and Quality Monitoring

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• Vericiguat to slow calcific aortic valve narrowing

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  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT07715279

• CHATEAU Registry: Real-world outcomes after TAVR

  This registry collects real-world data from adults who had TAVR between 2021 and 2025 to see how they do over time and how valve performance holds up.

  Recruiting Eunpyeong St. Mary's Hospital · Seoul · NCT07709858

• Impact of TAVR on kidney function in people with aortic valve disease

  This registry tests how trans-catheter aortic valve implantation affects kidney function and the risk of kidney injury in adults with aortic stenosis.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT07626710

• Hydra THV Transfemoral Valve Implantation in Severe Aortic Stenosis

  This registry tests how safely and effectively the Hydra THV works when implanted through the femoral artery in adults with severe symptomatic aortic stenosis.

  Recruiting at 8 sites Fundación EPIC · Aravaca and 7 other locations · NCT07566624

• How the type of sedation affects recovery after TAVR

  This study will test whether three common sedation approaches (propofol, dexmedetomidine, or midazolam with fentanyl) change how people recover on the first day after transfemoral TAVR.

  Recruiting Phase 4 Endeavor Health · Glenview, Illinois · NCT07556523

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.