Sponsor or institution
Clinical trials and research at University of Pittsburgh
As of November 12, 2026, Find a Trial lists 271 clinical trials run by University of Pittsburgh that are recruiting, at sites in 4 countries (most in United States (266), India (5), Canada (1)). By phase: Phase 2 (31), Phase 4 (12), Early Phase 1 (12), Phase 1 (10). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 271Clinical trials
- 4Countries
Newest trials
All recruiting trials (newest 150 of 271)
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Imaging Mitochondrial Complex-I and Brain Metabolism in Alcohol Use Disorder
This study tests whether PET imaging with [18F]BCPP-EF and [18F]FDG can reveal differences in brain energy use between adults with alcohol use disorder and healthy controls, and whether these measures relate to relapse risk.
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Imaging Brain Mitochondrial Complex-I in Cocaine Use Disorder
This study uses a PET scan with [F-18]BCPP-EF to see how mitochondrial Complex-I activity in the brain differs between people with cocaine use disorder and healthy controls.
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Managing nighttime voiding in older women with sleep strategies
This study tests whether brief behavioral sleep therapy and mindfulness, alone or together, reduce how often older women wake at night to urinate and how much urine they produce at night.
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Personalized pain relief for knee OA using central nervous system-based duloxetine
This study tests whether duloxetine can improve walking and daily activity in people with knee osteoarthritis by comparing it to a placebo.
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Which antibiotic works best for kids with sinus infections?
This study tests whether amoxicillin, amoxicillin-clavulanate, or a placebo help children with acute sinusitis feel better faster.
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Comparing Antibiotics and Placebo for Ear Infections in Toddlers
This trial tests whether amoxicillin, amoxicillin-clavulanate, or a placebo help reduce symptoms in children with acute otitis media.
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Caregiver-Adolescent Dating Violence Prevention Program for Sexual and Gender Diverse Youth
This pilot tests FLARE, a dating-violence prevention program for SGDY and their trusted adults to see if it’s acceptable, feasible, and ready to use in real settings.
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Dorsal Root Electrical Stimulation to Help Spasticity in Children with Cerebral Palsy
This study tests whether adding dorsal root electrical stimulation during SDR surgery can lessen spasticity in children with cerebral palsy.
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Facial Vein Reconstruction to Prevent Lymphedema After Neck Surgery for Head and Neck Cancer
This trial tests whether reconnecting the facial vein after neck dissection can reduce lymphedema in adults treated for head and neck cancer.
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Precision management of urinary tract symptoms in older women
This trial tests three ways to treat urinary tract symptoms in women 65 and older to see which approach works best and minimizes unnecessary antibiotic use.
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Extended azithromycin treatment in prelabor rupture of membranes at periviable gestations
This study tests whether giving extra doses of azithromycin beyond the standard antibiotics can improve outcomes for pregnant people with PPROM between 22 and 28 weeks.
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Smartphone-based Intervention for Young Adults with ADHD and Risky Drinking
A smartphone-based program is tested to see if it's doable and helpful for young adults with ADHD who also drink at risky levels.
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Effect of Resistance Training on Muscle Mass and Mental Health in Adults on Obesity Medication
This study tests whether 60 minutes of resistance training twice a week for 3 months helps people on GLP-1 RAs keep muscle and feel mentally better.
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Bevonescein to Improve Nerve Visualization During Thyroidectomy
A new fluorescence agent called bevonescein is tested to help visualize nerves during thyroid surgery to see if it improves voice outcomes for patients with thyroid disease.
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Axelopran and Nivolumab in PD-1-Refractory Metastatic Melanoma
This study tests whether adding axelopran to nivolumab can help people whose melanoma no longer responds to PD-1 therapy.
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tSCS for improving leg strength and walking in kids with spina bifida
This pilot test will try non-invasive transcutaneous spinal cord stimulation to see if it helps improve leg muscle strength and walking in children with myelomeningocele who can walk a little with help.
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Imaging brain stress systems in people with heavy drinking to see if cortisol boosts NOP signals
In people with heavy drinking, this PET study tests whether hydrocortisone increases NOP receptor binding more than in healthy controls, to see if this relates to relapse risk.
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Mobile home BP monitoring with coaching after high blood pressure from pregnancy
This program tests whether a home blood pressure monitoring system plus virtual coaching can help midlife women, 10–20 years after a hypertensive pregnancy, manage high blood pressure better than usual care.
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Knee Replacement Rehabilitation Pathways
This study tests a new rehabilitation care pathway after knee replacement to see if it improves recovery for all patients and reduces differences between groups.
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Automated Sensing of IADLs to Measure Daily Activity in Older Adults
This study tests whether wearables, computer vision, and eye tracking can recognize everyday tasks like cooking and cleaning and compare the results with occupational therapists’ ratings in older adults living at home.
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GGC oral supplement in people with mild cognitive impairment
This study tests whether taking Gamma Glutamylcysteine (GGC) at different daily doses is safe and tolerable for adults with mild cognitive impairment over three months.
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Ridge Preservation With Collagen Membrane After Tooth Extraction
This study tests whether adding a resorbable collagen membrane to a bone graft improves jawbone preservation after tooth extraction for people who have significant buccal bone loss.
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Tirzepatide after adrenalectomy for MACS
This study tests whether adding tirzepatide after adrenalectomy helps control blood pressure and improve metabolic health in adults with mild autonomous cortisol secretion.
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Thiotepa-based Conditioning With Reduced Post-Transplant Cyclophosphamide for Allogeneic Stem Cell Transplant in High-Risk Blood C cancers
This phase 1 trial tests a Thiotepa, Busulfan, and Fludarabine conditioning regimen with de-escalated post-transplant cyclophosphamide to see if it can improve outcomes after allogeneic stem cell transplantation for high-risk blood cancers.
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Two surgical treatments for peri-implantitis: implantoplasty versus mechanical debridement
This tests whether adding implantoplasty to resective surgery reduces inflammation and improves outcomes around dental implants in adults with peri-implantitis.
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Nutrition and Kidney Health Program for adults with kidney disease
A nutrition and lifestyle program designed with patients and community partners will be tested to see if adults with kidney disease can benefit and stay engaged.
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Gentle spinal stimulation to reduce muscle tightness in children with cerebral palsy
This will try non-invasive, light spinal cord stimulation with movement tests to see if it reduces spasticity in children ages 5–17 with cerebral palsy.
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Flourish for middle and high school students affected by cyberbullying
This pilot will test Flourish, a text- and web-based program, to see if it helps middle and high school students who have experienced cyberbullying and are at risk for suicide.
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Feasibility of a perinatal smoking and cannabis cessation program
This study tests a perinatal program to help pregnant people quit tobacco and cannabis and stay smoke-free after birth.
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Rest, emotion, and arousal in autistic children ages 6–10
This study tests whether a caregiver-delivered "Power Down" bedtime massage can lower bedtime arousal and help sleep and daytime emotion regulation in autistic children ages 6–10 with sensory over-responsivity.
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Combined systemic and intraperitoneal chemotherapy for gastric cancer with peritoneal spread
This trial tests adding laparoscopic HIPEC to standard systemic chemotherapy for adults with peritoneal carcinomatosis from gastric cancer.
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Game-based tool to reduce alcohol use among youth
A game-based program called Singularities is being tested in teens to see if it lowers alcohol-related harms and helps them use protective strategies and healthier online habits.
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Vasectomy: Right for Me? — a web-based decision aid
A web-based decision aid helps men think clearly about vasectomy and other birth control options to see if it fits their goals.
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Window of Opportunity to Preserve Laryngeal Function
This trial will try a short course of platinum chemotherapy plus paclitaxel and the immunotherapy toripalimab before surgery to see if adults with advanced laryngeal or hypopharyngeal squamous cell cancer can keep their voice box and still get good cancer control.
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Blood test to find mild-to-moderate pancreatic enzyme insufficiency and guide enzyme treatment for people with pancreatitis
This project will use the Malabsorption Blood Test to find adults with recurrent acute or chronic pancreatitis who have mild-to-moderate exocrine pancreatic insufficiency and see if pancreatic enzyme replacement for responsive patients improves quality of life.
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Neck nerve stimulation to map spinal and brain sensory pathways
We will test whether brief electrical pulses applied to neck nerve roots can reveal spinal and brain sensory responses in people with chronic stroke and control patients undergoing cervical surgery.
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i-STAT Alinity whole-blood test for adults with head injury in the emergency department
This project will try the i-STAT Alinity whole-blood test in adults with recent mild head injuries (GCS 13–15) to see if it helps decide who needs a head CT.
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Pharmacist-guided medication management using pharmacogenomics to improve depression care
This study tests whether pharmacists in community pharmacies can use a patient's pharmacogenomic results to guide antidepressant treatment and improve Depression outcomes compared with usual care.
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Sleep and circadian interventions for college students at high risk of suicide
Three sleep-focused approaches are being tested to see if they can help reduce suicidal thoughts and depression in high-risk college students receiving psychiatric care.
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Brief topical cryotherapy before steroid injections for keloid and hypertrophic scars
This study will test whether applying a short burst of topical cryotherapy just before steroid injections lowers pain and makes injections easier for adults getting intralesional triamcinolone for keloid or hypertrophic scars.
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Tumor-informed ctDNA testing for people with small, early-stage triple-negative breast cancer
This project will test whether a highly sensitive tumor-informed blood test (ctDNA) can detect tumor DNA in people newly diagnosed with small, stage I triple-negative breast cancer before and during their treatment.
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Strategy training to improve attention for people with spatial neglect after stroke
This program tests whether metacognitive strategy training helps people with spatial neglect after stroke pay more attention and carry out daily activities more independently.
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PowerHeal Bioelectric Bandage for infected open wound recovery
This tests whether the PowerHeal™ Bioelectric Bandage helps adults with infected traumatic wounds heal faster and clear infection better than standard dressings.
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Kaempferol absorption and pharmacokinetics in healthy adults
This trial will test how oral kaempferol is absorbed and processed in healthy adults by measuring levels in blood and urine.
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Fat graft beneath penile skin graft during reconstruction
This study tests whether placing a small amount of a patient's own fat under the skin graft on the penis improves healing and cosmetic results after penile reconstruction.
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Why walking causes different amounts of knee pain in people with osteoarthritis
This project will see if differences in the brain, joint imaging, movement, and sensory responses explain why adults 45–80 with knee osteoarthritis have different levels of walking pain.
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How ketamine and propofol affect brain activity, memory, and pain
This project will test whether ketamine and propofol, given alone and in different orders, change brain activity, connectivity, and next-day memory in healthy adults aged 18–59.
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How teens' responses to social threat relate to relationships and suicidal thoughts
This study tests whether how girls assigned female at birth ages 12–17 pay attention to social threats relates to their daily relationships and suicidal thoughts or self-harm.
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Remimazolam effects on brain activity, pain response, and memory during MRI
This project sees if the sedative remimazolam changes thinking, pain responses, and brain connectivity in healthy adults aged 18–59 during MRI scans.
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Virtual reality to reduce pain and anxiety during first-trimester procedural abortion
This trial will test whether wearing a VR headset that shows a meditative nature video during a first-trimester procedural abortion reduces pain and anxiety and increases satisfaction compared with usual care.
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Topical 5% Niacinamide for Skin Cancer Prevention in Organ Transplant Recipients
This trial tests whether applying a 5% niacinamide cream daily, in addition to sunscreen, can reduce actinic keratoses and new skin cancers in adults who have had an organ transplant.
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Reduced-intensity hematopoietic stem cell transplant for CVID and other primary immune regulatory disorders
This will try a reduced-intensity hematopoietic stem cell transplant with low-dose total body irradiation to correct or improve severe CVID and related primary immune regulatory disorders in people aged 5 to 40.
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Testing a digital remote monitoring tool for patients with melanoma on immunotherapy
A digital remote monitoring program using wearables and self-reports is being tested to see if it’s easy to use and helps manage symptoms and quality of life for melanoma patients on immunotherapy.
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Mapping and stimulating brain–stomach connections in chronic nausea
This will test whether non-invasive brain stimulation (TMS) can change stomach activity and reduce nausea in adults with chronic nausea and in healthy volunteers.
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AchromoPhage for adults with cystic fibrosis and chronic Achromobacter lung infection
A small study tests a four-phage mix called AchromoPhage in adults with CF and long‑standing Achromobacter lung infection to see if it is safe and tolerable when given in different ways.
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Real-time app and wearable sensors to help young people control type 2 diabetes
This project will try a smartphone app together with a continuous glucose monitor and a Fitbit for English-speaking 16–24-year-olds diagnosed with type 2 diabetes before age 18 to learn which messages and features help with activity and glucose monitoring.
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Mobile health app (iMHere 2.0) for veterans with spinal cord injury and their family caregivers
Try an adapted iMHere 2.0 mobile app to help veterans with spinal cord injury and their family caregivers manage self-care and psychosocial needs.
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Active surveillance for small ER+ breast cancer in women 70 and older
This project will try active surveillance — regular imaging instead of immediate surgery or therapy — for women 70 and older with small, screen-detected ER+/HER2- breast cancers to see how many tumors grow within 12 months.
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Adding Air Quality Index information to help children with asthma
This project will test whether adding EPA or commercial Air Quality Index (AQI) information to asthma action plans helps children aged 8–17 with asthma have fewer flare-ups and better control.
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Backing up and restoring your brain's mood states (BandR)
This project tries to record a person's brain and body signals on a good day and then recreate that same state on a later bad day using personalized brain stimulation and neurofeedback for adults who experience mood swings.
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Tongue-out positioning to lower mouth and swallowing side effects in head and neck cancer
This trial will try a 'tongue-out' position during radiation to see if it lowers mouth sores, taste changes, and swallowing problems for people with oropharyngeal, laryngeal, or hypopharyngeal squamous cell carcinoma.
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Morning versus afternoon immunotherapy for advanced/metastatic NSCLC
This trial will try whether giving first-line anti-PD-1/PD-L1 immunotherapy in the morning versus later in the day improves outcomes for people with advanced or metastatic non-small cell lung cancer.
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Left atrial function in people with unexplained (cryptogenic) stroke.
This will see if lower left atrial strain on a heart ultrasound is linked to unexplained (cryptogenic) stroke and to higher risk of another stroke in adults who had a stroke without a known cause.
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Subcutaneous versus intravenous immune therapy: which do patients prefer?
This project will test whether patients with advanced cancers prefer subcutaneous (under‑the‑skin) versus intravenous nivolumab or, if available, pembrolizumab.
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Comparing two immunotherapy combinations and their immune effects in unresectable or metastatic melanoma
This will test whether two different first-line immunotherapy combinations produce different immune responses in tumors and blood of people with unresectable or metastatic melanoma.
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Detecting tumor DNA in blood of men with high-risk localized prostate cancer
This study will test whether a tumor-informed blood test can detect circulating tumor DNA before prostatectomy in men with high-risk localized prostate cancer.
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Try the PPAL powered bedside commode to make toileting transfers safer
This six-week at-home test will try a powered, height-adjustable PPAL bedside commode to see if it helps adults who have trouble transferring to a toilet with less physical help from caregivers.
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Bright green light to help recovery after laparoscopic or robotic surgery
This will test whether bright green light used after laparoscopic or robotic surgery helps adults have less pain, use fewer opioids, and sleep and feel better during recovery.
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Night-shift naps and their effects on blood pressure and performance
This project tests different nap lengths during night shifts to see if they restore normal nighttime blood pressure patterns and improve alertness for public safety and healthcare night shift workers.
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Health App Recommendation Tool to help dementia caregivers find suitable health apps.
This project will try the Health App Recommendation Tool (HART) with family caregivers of people with Alzheimer's disease or related dementias to see if it helps them find and use helpful health apps.
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Improving outcomes for youth with type 2 diabetes by addressing social needs
This project will try different ways to connect teens and young adults with type 2 diabetes and their families to social supports and resources to help with diabetes care.
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Plasma Resuscitation Early for Severe Burn Injury
This trial tests whether starting plasma resuscitation right at hospital arrival helps adults with large burns recover better than standard fluids.
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Testing CARES, an integrated screening and stepped-care program, versus standard care in cancer clinics
This trial will test whether CARES helps adults with cancer reduce pain, fatigue, and depression and start treatment more often than standard care.
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Doula support to reduce partner violence during pregnancy and early postpartum
This project will test whether pairing pregnant people who have experienced intimate partner violence with IPV-trained doulas during pregnancy, birth, and the first months after delivery reduces partner violence and improves related health outcomes compared with an active control.
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Cervical spinal cord stimulation plus physical therapy for chronic post-stroke arm weakness
This study will test whether adding cervical spinal cord stimulation to physical therapy helps adults with chronic arm and hand weakness after a stroke move and use their arm better.
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Fast In‑Bed Tracking (FIT) weight-loss program using a bed-integrated scale for wheelchair users
We will test whether giving overweight wheelchair users a bed-integrated smart scale alongside an adapted weight-loss program helps them lose more weight than the program alone.
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Testing the NUN biomarker to guide dry needling for myofascial low back pain.
This study will try to see if the NUN biomarker changes after dry needling and can predict who with chronic myofascial low back pain will feel better.
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Animal versus plant protein smoothies and their effects on metabolism and immune signaling
This trial will test whether drinking animal-based, plant-based, or plant-based plus leucine protein smoothies changes blood amino acids and metabolic and immune responses in healthy adults.
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Psychosocial and behavioral support for stem cell transplant patients and their family caregivers
This project tests two brief four-session video counseling programs to help stem cell transplant patients and their family caregivers manage care and stick to medical instructions after hospital discharge.
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Povidone-iodine versus chlorhexidine wound wash after total hip replacement
We will test whether washing the surgical wound with povidone-iodine or chlorhexidine helps wounds heal better after total hip replacement in people with hip osteoarthritis or avascular necrosis of the femoral head.
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Intravenous iron for bleeding symptoms in iron-deficient people with inherited bleeding disorders
This single-center study will try IV iron infusions to see if they reduce bleeding symptoms and improve quality of life for people over 15 with inherited bleeding disorders and low iron (ferritin <50 ng/mL).
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Sparrow Link device to help with opioid withdrawal in hospitalized adults with OUD
A wearable nerve-stimulation device is being tested to see if it can help reduce withdrawal symptoms in adults with opioid use disorder who are hospitalized and receiving standard care.
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Increase brain and blood glutathione with gamma‑glutamylcysteine in early Parkinson's
This will test whether daily gamma‑glutamylcysteine supplements raise brain and blood glutathione and improve motor, thinking, and gut symptoms in people with early Parkinson's.
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Stimulating the motor thalamus and surface cortex to improve movement and speech
This test tries brief electrical stimulation of the motor thalamus (VOP/VIM) and nearby cortex during DBS surgery to see if it improves movement, grip strength, and speech in people having DBS for Parkinson's disease, essential tremor, stroke, or brain injury.
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Motor thalamus deep brain stimulation to improve movement and speech
This trial will test turning deep brain stimulation on and off in adults who already have DBS implants for movement disorders to see if stimulation improves arm and hand movement, facial movement, speech, and swallowing.
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Penile lengthening with RestoreX before inflatable penile prosthesis surgery
This test tries whether using the RestoreX penile traction device for several weeks before inflatable penile prosthesis surgery helps men with erectile dysfunction get a longer implant.
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Gamma‑glutamylcysteine to raise brain glutathione in people with repetitive head impacts
This trial will test whether an oral supplement called GGC can get into the brain and raise antioxidant glutathione levels in people with a history of repetitive head impacts, such as retired NFL players or combat veterans.
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Perelel versus generic prenatal vitamins for mother and baby health
This test will see if taking Perelel prenatal vitamins instead of a generic prenatal vitamin during pregnancy changes blood nutrient levels for pregnant people with food insecurity.
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Clinic-based program to prevent teen dating violence for adolescents and caregivers
This pilot will try a clinic-delivered program that helps teens (ages 12–16) and their caregivers improve communication and reduce dating violence during routine pediatric well visits.
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Specialized cardiac-arrest care after resuscitation
We test whether moving adults who survived a cardiac arrest outside the hospital to a regional cardiac arrest center helps them recover better after 90 days.
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Helping pregnant people manage ADHD symptoms during pregnancy and after birth
This trial will test a behavioral program called MomMA to help pregnant people with ADHD manage their symptoms during pregnancy and after the baby is born.
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Technology-assisted stepped collaborative care for pain, fatigue, and depression in dialysis patients
This trial tests whether a technology-assisted stepped collaborative care program — combining medications and/or cognitive behavioral therapy delivered with dialysis staff support and telemedicine — can reduce pain, fatigue, and depression in adults on in-center hemodialysis.
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Rapid brain stimulation patterns to boost mood in adults with major depressive disorder
This study tests different non-invasive brain stimulation patterns to see if they improve mood for adults with major depressive disorder, and how these patterns work with antidepressant treatments.
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Sleep and bright-light program for teens with depression and sleep problems
This project will try a sleep-and-bright-light program to improve sleep and mood in teens aged 12–18 with moderate-to-severe depression and clinically significant sleep problems who are at risk for suicidal thoughts.
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Bedside ultrasound to guide diuretics in hospitalized acute heart failure
This project tests whether using bedside ultrasound of the right internal jugular vein to guide IV diuretics helps adults hospitalized with acute decompensated heart failure and low RIJV distensibility avoid excess fluid, kidney injury, and readmission.
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9‑ING‑41 and retifanlimab with modified FOLFIRINOX for advanced pancreatic cancer
This tests whether adding the GSK‑3β inhibitor 9‑ING‑41 and the PD‑1 antibody retifanlimab to modified FOLFIRINOX helps people with advanced pancreatic cancer who have not had prior systemic therapy for their advanced disease.
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AI-guided eardrum photos to improve diagnosis of ear infections in infants
This will test an AI app that reads photos of infants' eardrums to see if it changes how doctors diagnose ear infections and prescribe antibiotics for children 6–24 months with cold symptoms.
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Voiceitt app for improving communication in people with speech impairments
This study tests if the Voiceitt app can help people with speech impairments, like those from cerebral palsy or stroke, communicate better.
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Prehabilitation with exercise and nutrition before esophagectomy for esophageal cancer
This program will test if exercise plus nutrition before esophagectomy is doable and acceptable for adults with esophageal cancer.
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Autologous Fat Grafting for Immediate Soft-Tissue Reconstruction After Injury
This study tests whether using the patient's own fat tissue, added at the time of skin grafting, can better repair severe soft-tissue injuries and reduce scarring in adults with burns or trauma.
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Autologous layered fat-and-skin grafting for post-burn scar contracture
This study tests whether using a patient’s own fat layer plus a skin graft can match the results of a full-thickness skin graft for delayed reconstruction of burn- or trauma-related scar contractures.
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Testing exercise programs with and without rest for knee osteoarthritis
This study is testing two different exercise programs for people with knee osteoarthritis to see if taking longer breaks during workouts helps them feel better and move easier.
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Using special imaging to reduce throat surgery complications
This study tests if using special imaging during throat surgery can help reduce complications, like infections, for patients with throat cancer.
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Evaluating hypoxia in primary melanoma
This study is trying to see if low oxygen levels in early-stage melanoma tumors can help predict how well patients will do after treatment.
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Digital Behavioral Activation for At-risk Youth
This study is testing a new app called Vira, along with help from health coaches, to see if it can encourage at-risk teens to engage in positive activities and improve their mood and mental health.
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Needle-free ear cryo-stimulation and brain imaging for chronic low back pain
This trial will test whether needle-free ear cryo-stimulation can change brain activity and reduce pain in adults who have had daily low back pain for at least six months.
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Brain responses to gentle ear stimulation measured with near-infrared light
This one-visit test uses gentle ear stimulation and near-infrared head sensors to see how healthy adults' brains respond.
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Combining Acceptance and Commitment Therapy with Vestibular Rehabilitation for mTBI
This study is testing if combining a therapy that helps with acceptance and commitment with standard balance exercises can better help military service members with mild traumatic brain injury and related symptoms feel better.
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Understanding how social media impacts the teen brain and depression
This study is testing how using social media affects the feelings and brain activity of teenagers who show signs of depression.
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Understanding how GEMIN5-related neurodevelopmental disorder develops over time
We will collect medical records, clinic exam data, and blood samples to see how GEMIN5-related neurodevelopmental disorder progresses in people of all ages who have two GEMIN5 gene mutations.
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Treatment of Medium Chain Acyl-CoA Dehydrogenase Deficiency with Sodium Phenylbutyrate
This study is testing if sodium phenylbutyrate can safely help people aged 4 and older with medium-chain acyl-CoA dehydrogenase deficiency feel better.
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Restoring social participation after chronic stroke with strategy training plus acceptance and commitment therapy
This program will test whether adding acceptance and commitment therapy to strategy training helps adults living with chronic stroke reconnect with social activities.
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Using your own fresh and frozen fat to restore facial volume after injury
This trial will try taking extra fat at one operation, freezing it, and reusing it three months later to restore facial volume in adults with post‑traumatic craniofacial defects.
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Effects of cannabis on sleep and light sensitivity in young adults
This study tests how using and stopping cannabis affects sleep and light sensitivity in young adults aged 18 to 25.
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Coaching parents to boost happiness in 4–6-year-old children
This test sees if three brief parent coaching sessions that encourage child positive emotions can increase reward-related brain responses in 4–6-year-old children of mothers with elevated depression.
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Combining Zanzalintinib with Immunotherapy for Liver Cancer
This study is testing a new combination of a cancer drug and immunotherapy to see if it can help people with advanced liver cancer feel better and fight their disease.
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Using a wearable device to improve symptoms in systemic sclerosis patients
This study is testing if wearing a special device can help people with systemic sclerosis feel less tired and manage their symptoms better.
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Injection of sodium thiosulfate for treating calcinosis
This study is testing if injections of sodium thiosulfate can safely help people with calcinosis related to conditions like systemic sclerosis and dermatomyositis feel better and reduce their symptoms.
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Monitoring tumor changes in metastatic lobular breast cancer using blood tests
This study is testing if tracking changes in tumor DNA from blood tests can help doctors better understand how well treatment is working for patients with advanced lobular breast cancer.
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Pip Care: personalized perioperative app and coach for surgical patients
This project tests whether a HIPAA-compliant app plus a live health coach (Pip) helps adults having planned inpatient abdominal and related surgeries better prepare for and recover from surgery.
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Using a vagal stimulator to reduce the need for nasogastric tubes after surgery
This study is testing if a vagal nerve stimulator can help adults recover from surgery faster and reduce the need for uncomfortable feeding tubes.
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Comparing two 8-week programs to improve mood, sleep, and suicidal thoughts in people 55 and older.
This trial will test whether one of two weekly 8-week behavioral programs helps people aged 55+ with depression and recent suicidal thoughts or past suicide attempts sleep better and feel less depressed.
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Methadone-enhanced recovery for children having posterior spine fusion
This trial will test whether a multidose methadone-based enhanced recovery protocol reduces pain and opioid use in children (ages 10–17) undergoing posterior spine fusion for idiopathic scoliosis.
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Methadone-based pain control for children having elective heart surgery
This trial will try a standardized methadone-based recovery plan to see if it reduces pain, opioid use, and side effects for children aged 3 to under 18 after planned heart surgery compared with usual care.
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Exploring how different amounts of resistance exercise affect heart health
This study is testing how different amounts of resistance exercise can improve heart health in people at risk for cardiovascular disease.
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Brain stimulation to reduce emotional stress responses
This study is testing if a type of brain stimulation can help healthy people manage their emotional reactions to stress better.
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Impact of anti-PD1 therapy on atypical nevi in melanoma patients
This study is testing whether anti-PD1 therapy can help prevent melanoma by looking at changes in unusual moles in patients who have had melanoma before.
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Reducing unnecessary anticholinergic medications in schizophrenia
This study tests if stopping unnecessary anticholinergic medications can help people with schizophrenia feel better and improve their daily functioning.
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Using interferon-γ and donor cells to treat relapsed leukemia after stem cell transplant
This study is testing if a combination of interferon-γ and donor cells can help people with relapsed leukemia after a stem cell transplant feel better and improve their chances of recovery.
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Cognitive Training Added to Ketamine for Depression in Real-World Clinics
This study tests whether adding computer-based cognitive training to ketamine or esketamine treatment helps depression improve faster and stay improved.
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Using acetazolamide to treat central sleep apnea in patients with opioid use disorder
This study is testing if the medication acetazolamide can help people with central sleep apnea who are being treated for opioid use disorder feel better and improve their sleep quality.
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Continuous jugular venous oxygen saturation monitoring after cardiac arrest
This project will test continuous and intermittent jugular venous oxygen saturation monitoring in adults who are comatose after cardiac arrest to see if brain oxygen delivery patterns can be detected and tracked.
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Yoga to help reduce tobacco cravings
This study is testing if yoga can help people who are dependent on tobacco reduce their cravings and possibly quit smoking.
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Diet changes for cancer patients on immune therapy
This study is testing if changing the diet of cancer patients on immune therapy with high-fermented foods and high-fiber supplements can improve their gut health and help their treatment work better.
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Improving mental health resilience in young tribal adults through Ultimate Frisbee
This study is testing a new program using Ultimate Frisbee to see if it can help young tribal adults in South India build better mental health resilience.
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Efficacy of an electronic intervention for adolescent suicide attempters
This study tests a new online program to help teenagers who have recently tried to harm themselves improve their coping skills and reduce the chances of future suicide attempts.
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Yoga for improving thinking skills in people with unipolar depression
This study is testing if regular yoga sessions can help people who have recovered from unipolar depression improve their thinking skills.
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Exploring how mothers' emotions affect suicide risk in children
This study is trying to see if teaching mothers better ways to handle their emotions can help reduce the risk of suicidal thoughts and behaviors in their children.
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Brain imaging of how people with and without cerebellar stroke hear and produce speech
We will use EEG and high‑field MRI to see if brain areas that plan movement and process speech work differently in healthy adults and people who've had a cerebellar stroke.
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Hormonal intervention to prevent injuries in military personnel during training
This study is testing whether hormone therapy can help military personnel train better and avoid injuries during tough training sessions.
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Combining Apimostinel with Cognitive Training for Treating Depression
This study is testing if a new depression medication called apimostinel, combined with brain training, can help people with major depressive disorder feel better for longer.
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Training college health providers to support transgender and gender diverse students
This study is testing a new training program for college health providers to see if it helps them better support transgender and gender diverse students who may face issues like sexual violence and drinking problems.
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Real-time engagement app to improve glycemic control in adolescents and young adults with type 2 diabetes
A smartphone app that combines glucose, activity, and diet data is tested to see if it helps teens and young adults with type 2 diabetes manage their blood sugar better.
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Digital cognitive behavioral therapy with peer support for young adults with sickle cell pain
This study is testing if a new online therapy with peer support can help young adults with sickle cell disease manage their pain better than standard care.
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Impact of Liver Volume Changes on Radiation Therapy for Abdominal Cancers
This study is testing how changes in liver size, caused by things like diet, affect the effectiveness of radiation therapy for people with upper abdominal cancers.
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Using triheptanoin to treat children with Pyruvate Dehydrogenase Complex Deficiency
This study is testing if a medication called triheptanoin can help children with Pyruvate Dehydrogenase Complex Deficiency feel better and improve their health.
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Using deep brain stimulation to improve speech and arm function after stroke
This study is testing if deep brain stimulation can help improve hand movement and speech in people who have had a stroke.
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Impact of Parenthood on Health in People with Cystic Fibrosis
This study looks at how becoming a parent affects the health of people with cystic fibrosis, especially their lung function and mental well-being, over five years.
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Remote training program for manual wheelchair skills
This study tests whether a remote training program with peer coaching can help people improve their manual wheelchair skills and mobility.
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Using low-dose aspirin after preeclampsia to improve recovery
This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.
Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.
Quick answers
How many clinical trials run by University of Pittsburgh are recruiting right now?
271, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (266 trials), India (5 trials), Canada (1 trial), Ukraine (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 31, Phase 4: 12, Early Phase 1: 12, Phase 1: 10. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.