Ridge Preservation With Collagen Membrane After Tooth Extraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants undergoing extraction of a single-rooted maxillary tooth with at least 30% buccal dehiscence will be randomly assigned to receive either ABCC graft alone or ABCC graft plus a collagen membrane. Healing will be evaluated around 4 months using CBCT scans, digital intraoral scans, and clinical measurements to see how well the ridge width, height, and contour are preserved, as well as soft tissue healing and safety. Patient-reported outcomes such as pain and satisfaction will also be collected, and a subset may have bone samples analyzed for healing. Implant placement will occur after healing to assess long-term suitability of the preserved ridge.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-80
* Indicated for extraction of a single-rooted maxillary tooth
* ≥ 30% buccal bone dehiscence confirmed by CBCT reconstructions
* Presence of both adjacent teeth
* No interproximal bone loss
* ASA I-II health status
* Ability to comply with required procedures, including attending required number of clinic visits

Exclusion Criteria:

* Patients diagnosed with periodontitis adjacent to the area to be treated
* History of allergic reactions to local anesthetics or bone graft material (self-reported);
* Current heavy smokers (≥ 10 cigarettes/day) or those who quit smoking recently (self-reported; last 6 months);
* Diagnosis of diabetes mellitus, liver or kidney failure (self-reported);
* Presence of active infectious diseases of any kind;
* History of chemotherapy or radiation therapy to the head or neck within the past 5 years (self-reported);
* Severe hematologic disorders (risk for hemorrhage)(self-reported);
* Assumption of corticosteroids, IV bisphosphonates or immunosuppressive drugs;
* Any history of alcohol or drug abuse (self-reported);
* Pregnancy or plans to become pregnant within 4 months of study enrollment (self-reported);

Where it's running

• University of Pittsburgh School of Dental Medicine, Department of Periodontics and Preventive Dentistry
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Debora R Dias, DDS, PhD — University of Pittsburgh, Department of Periodontics and Preventive Dentistry
• Study coordinator: Debora R Dias, DDS, PhD
• Email: deboradias@pitt.edu
• Phone: 4126488595

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.