Brief topical cryotherapy before steroid injections for keloid and hypertrophic scars

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3 interventional trial enrolls adults with keloid or hypertrophic scars who are already scheduled for intralesional triamcinolone. Each eligible scar is split into two comparable regions; one half receives brief liquid nitrogen cryotherapy immediately before the steroid injection and the other half receives the steroid injection alone. Participants rate pain after each injection on a 0–10 numeric scale and clinicians rate injection resistance for each half. The within-scar split design compares patient-reported pain and provider-assessed resistance directly between the two techniques.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (≥18 years) with keloids or hypertrophic scars already scheduled to receive intralesional triamcinolone (TAC) as part of routine care.
* At least one keloid or hypertrophic scar with two comparable regions (≥2 cm each) suitable for split-treatment.
* Able to provide informed consent and complete pain assessments in English.

Exclusion Criteria:

* Keloid or hypertrophic scar located on the face (except earlobes), excluded for cosmetic reasons.
* Prior treatment to the study-selected keloid/hypertrophic scar based on self-report.
* Inability to complete study assessments due to cognitive or language barriers.

Where it's running

• University of Pittsburgh
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Sonal Choudhary — University of Pittsburgh
• Study coordinator: Sonal Choudhary, MD
• Email: choudharys@upmc.edu
• Phone: 7867182737

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.