Remimazolam effects on brain activity, pain response, and memory during MRI

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a single-arm early-phase fMRI protocol, adult participants receive remimazolam while undergoing resting-state and task-based MRI scans. Brain activity will be recorded at rest, during mild electric nerve stimulation to produce noxious input, and while participants perform a memory encoding task. Researchers will compare functional connectivity and activation patterns before, during, and after drug administration to characterize cognitive and nociceptive effects. Enrollees are healthy adults 18–59 without major medical, neurological, or psychiatric conditions and with no MRI contraindications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults 18-59 years of age, who:
* have none of the specific exclusion criteria
* have a valid email address and valid phone number throughout the study
* free from any non-MRI compatible implants

Exclusion Criteria:

* are pregnant or attempting to conceive
* body mass index (BMI) \> 35
* significant memory impairment or hearing loss
* sleep apnea
* chronic pain or frequently taking pain medication (including tramadol)
* chronic medical conditions requiring treatment (hypertension, diabetes, high cholesterol)
* neurologic disease, including seizures and tremor
* psychiatric diagnoses, including anxiety, depression, panic, or PTSD
* a history of any of these medical conditions: abnormal heartbeats (cardiac conduction abnormality or arrhythmia), liver or kidney disease, or significant lung disease
* severe claustrophobia or MRI intolerance
* have metal implants or non-removable metal piercings
* having a history of adverse reaction to midazolam (Versed), lorazepam (Ativan) or another benzodiazepine class medication
* are allergic to dextran
* daily alcohol or heavy alcohol use; history of alcohol abuse
* current daily smoker
* regular or recent marijuana use (including prescribed/medical marijuana)
* illicit drug use, i.e., street drugs
* regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids

Where it's running

• University of Pittsburgh
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Keith M Vogt, MD, PhD — University of Pittsburgh
• Study coordinator: Keith M Vogt, MD, PhD
• Email: kev18@pitt.edu
• Phone: 4126473147

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Effects of Remimazolam on Brain Activity in Children

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.