Pharmacist-guided medication management using pharmacogenomics to improve depression care

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial explores if comprehensive medication management that incorporates pharmacogenomic results, delivered by pharmacists in community pharmacies, can lead to better depressive symptoms and medication outcomes. Eligible adults with mild or greater depressive symptoms who are starting or adjusting antidepressants and have PGx data will be randomized to PGx-guided care or usual care. Participants in the control arm will receive their PGx results at study end. The study compares outcomes between groups to see if PGx-informed collaboration among pharmacists, prescribers, and patients improves treatment effectiveness.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA:

* At targeted community pharmacy for:

  * New prescription or change in dose/schedule of SSRI (citalopram, escitalopram, sertraline, paroxetine), OR
  * Concurrent SSRI (citalopram, escitalopram, sertraline, paroxetine) and new prescription/change in SNRI (desvenlafaxine, duloxetine, and venlafaxine) / bupropion.
* Depressive symptoms confirmed by PHQ8 assessment (\>5 indicating at least mild depressive symptoms)
* UPMC patient (or able/willing to become one) and has UPMC provider (or able/willing to obtain one)
* Signed consent to join Pitt+Me Discovery biobanking research study.
* English-speaking

EXCLUSION CRITERIA:

* Inability to receive CMM at specific pharmacy/pharmacist
* Comorbid diagnosis of schizophrenia (patient-reported)
* Untreated sleep disorder (patient-reported)
* Pitt+Me Discovery participant who has elected to not receive return of results, or who has already received results previously

Where it's running

• University of Pittsburgh
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Philip E Empey, PharmD, PhD — University of Pittsburgh
• Study coordinator: Linda Prebehalla, RN
• Email: CompassPGx@pitt.edu
• Phone: (412) 624-8129

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.