Perelel versus generic prenatal vitamins for mother and baby health
Official title: Impact of Perelel Trimester-Specific Dietary Supplements vs. Generic Prenatal Supplements on Maternal and Fetal Health Outcomes: A Randomized Controlled Trial
Run by University of Pittsburgh · NCT07046845 · Data updated 2026-11-12
This test will see if taking Perelel prenatal vitamins instead of a generic prenatal vitamin during pregnancy changes blood nutrient levels for pregnant people with food insecurity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years and up |
| Sex | Women only |
| Enrollment | 600 (estimated) |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Status | Recruiting |
| Started | January 7, 2026 |
| Main results expected | February 2027 |
| Study ends | June 2027 |
| Registry record updated | February 4, 2026 |
| Trial ID | NCT07046845 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pregnant people under 12 weeks with a single fetus who identify as food insecure, receive prenatal care at a Magee-Womens Hospital practice, and are not currently taking prenatal supplements.
✕Probably not a fit
People already taking prenatal vitamins, those with multiple pregnancies, known fetal chromosomal or structural defects, malabsorption conditions, treated thyroid disease, ongoing steroid use, or those not receiving care at Magee-Womens Hospital are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Pregnant participants under 12 weeks with a single fetus who identify as food insecure and receive care at Magee-Womens Hospital will be enrolled and asked to take either Perelel or a generic prenatal supplement daily through pregnancy. Participants will come to UPMC Magee-Womens Hospital once each trimester for blood draws and questionnaires to measure nutritional markers, and a separate observational group will have a one-time first-trimester blood test and questionnaire to compare those with and without food insecurity. Key exclusions include current prenatal supplement use, known fetal chromosomal or structural defects, conditions that prevent nutrient absorption, medically treated thyroid disorder, or ongoing steroid use. The study measures changes in blood nutritional markers rather than clinical pregnancy outcomes.
Why it matters
Potential benefit: If successful, this could show that one prenatal formulation produces better maternal nutrient markers and help reduce nutrient deficiencies during pregnancy.
How similar studies have gone: Previous research shows prenatal vitamins generally improve nutrient levels in pregnancy, but direct head-to-head comparisons of specific branded formulations like Perelel versus generics are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Pregnant with only one baby 2. Identify as having food insecurity 3. Receiving care at a Magee-Womens Hospital associated prenatal practice 4. Less than 12 weeks' of pregnancy Exclusion Criteria: 1. Currently using prenatal supplement(s) 2. Unborn baby (fetus) identified as having a chromosomal or structural defect 3. Have a condition that prevents absorption of nutrients from food 4. History of medically treated thyroid disorder 5. Ongoing steroid use
Where it's running
-
UPMC Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Hyagriv Simhan, MD — Magee-Women's Research Institute
- Study coordinator: Jeanette Boyce, RNC, MSN
- Email: tessje@upmc.edu
- Phone: 412-641-4072
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Pregnant Women Living with HIV on Bictegravir/Emtricitabine/Tenofovir Alafenamide
This study looks at how B/F/TAF is used in pregnant women with HIV and whether it helps maintain viral suppression from before conception through delivery.
-
Pelvic Floor Training and a Modified Lumbopelvic Belt for Symphysis Pubis Pain in Pregnancy
This study tests whether pelvic floor muscle training plus a modified lumbopelvic belt can reduce pain and improve function for pregnant women with symphysis pubis pain.
-
Effective Communication in VBAC Counseling
This study tests how clearly doctors and midwives explain VBAC options during prenatal visits and whether patients feel understood.
-
Innovative Multidisciplinary and Virtual Care for IBD in Pregnancy
This study tests a dedicated IBD pregnancy care model, including a new virtual approach, to see if it improves access and quality of care for pregnant people with Crohn's disease or ulcerative colitis.
-
Compare spinal-epidural versus general anesthesia for babies after cesarean delivery
This trial tests whether the type of anesthesia used for cesarean delivery affects newborn hearing in babies.
-
Pregnant women weight-management support via an app and care model
Aims to try a smartphone-based weight-management program plus professional support for pregnant women to see if it helps manage gestational weight and promote healthy behaviors.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.