Testing exercise programs with and without rest for knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot trial evaluates the feasibility of two different exercise programs for individuals with knee osteoarthritis. Participants will be randomly assigned to either an exercise program with standard resting intervals or one with extended rest periods. Both groups will engage in the exercise regimen three times a week for 12 weeks, with assessments conducted before and after the program to measure outcomes such as gait, muscle strength, and physical performance. The study also includes the collection of blood and synovial fluid samples for further analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 45 and 79 yo.
* Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.
* BMI range \< 35 kg/m2.
* Sedentary lifestyle
* Knee joint is the most painful joint in the body.
* Ability to speak and understand English.
* Willingness to comply with all study procedures and be available for the duration of the study.

Exclusion Criteria:

* Non-OA disease of the knee.
* Advanced knee osteoarthritis
* Knee injection in the past 3 months.
* Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..
* Participate in regular exercise or physical activity .
* Participation in an intervention study for knee OA.
* Currently using a cane, walker or crutches to walk.
* History of cardiovascular disease or hypertension not controlled by medication.
* Two or more unexplained falls in the past year.
* Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.
* Contraindication to MRI.
* Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures.
* Pregnant female.
* Acute or terminal illness.

Where it's running

• University of Pittsburgh
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Sara Piva — University of Pittsburgh
• Study coordinator: Gaupp
• Email: awg26@pitt.edu
• Phone: 412-383-0742

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.