Specialized cardiac-arrest care after resuscitation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial compares transfer to a specialty cardiac arrest center versus usual care at the nearest hospital for adults resuscitated from out-of-hospital cardiac arrest. All participants receive standard treatments, with the key difference being the care setting they are transferred to after the ED visit. Researchers will follow up at 90 days to assess functional recovery and overall status. The study leverages a regional network of 18 hospitals to evaluate if specialized center resources and protocols improve outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Out-of-hospital cardiac arrest
* Resuscitated from cardiac arrest with palpable pulse in the emergency department
* Treated at one of participating hospital emergency departments
* Age ≥18 years

Exclusion Criteria:

* Known prior advanced directives or decision to limit critical care
* Known pre-arrest dependent functional status (e.g., living in a skilled nursing facility, hospice or bedbound)
* Arrest in the emergency department \>4 hours after arrival
* Traumatic etiology of arrest
* Known to have opted-out from the SPARC trial

Where it's running

• University of Pittsburgh Department of Emergency Medicine
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Jonathan Elmer, MD, MS — University of Pittsburgh
• Study coordinator: Sara DiFiore-Sprouse
• Email: difioresm@upmc.edu
• Phone: 4128642284

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding ventilation quality during in-hospital cardiac arrest

  This study is testing how different breathing techniques during CPR can help adults who have a cardiac arrest in the hospital survive better.

  Recruiting at 11 sites University of Aarhus · Aabenraa and 10 other locations · NCT06809309

• Smartphone-based EEG to detect hidden awareness in ICU patients with brain injuries

  Researchers will test a smartphone-enabled EEG to see if it can reveal Cognitive Motor Dissociation in ICU patients who can’t show commands at bedside.

  Recruiting Columbia University · Miami, Florida and 8 other locations · NCT07917728

• Physiology-guided Epinephrine Dosing in Pediatric Cardiac Arrest

  This observational study looks at how a child’s body responds to epinephrine during in-hospital cardiac arrests to see if dosing can be guided by physiology.

  Recruiting at 22 sites Children's Hospital of Philadelphia · Orange, California and 21 other locations · NCT07890610

• Hand position during chest compressions: interlocked fingers vs. overlapped hands

  This study tests whether having hands interlocked or stacked on top of each other during CPR chest compressions is non-inferior in depth and is compared for comfort and fatigue in a simulated setting.

  Recruiting University of Pecs · Pécs · NCT07825805

• Risk of malignant arrhythmias after acute coronary syndrome

  This study tracks how often dangerous heart rhythms occur in adults admitted for ACS and looks for patterns that might predict them.

  Recruiting Catharina Ziekenhuis Eindhoven · Eindhoven, North Brabant · NCT07824050

• Hyperacute Neurobiomarker Kinetics in Acute Brain Injury: What Happens in Minutes After Injury

  This study tests how early brain injury biomarkers behave in the first minutes to hours after traumatic brain injury or cardiac arrest to see if they rise quickly enough to help with early care.

  Recruiting at 4 sites University of Pecs · Pécs, Branya and 3 other locations · NCT07782216

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.