Exploring how different amounts of resistance exercise affect heart health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project investigates the dose-response relationship between resistance exercise (RE) and cardiovascular health, focusing on how varying durations of RE impact cardiovascular disease (CVD) risk factors. Participants will be randomly assigned to one of four groups, receiving either no RE or 30, 60, or 120 minutes of RE weekly, alongside a consistent aerobic exercise regimen. The study will track participants' health metrics over one year, including physical examinations and lifestyle education, to determine the optimal amount of RE for improving heart health. The first six months will involve supervised exercise sessions, while the latter half will assess adherence in a free-living environment with access to a health club.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Non-Smoker
* Overweight or Obese: Body Mass Index 25-43 kg/m2
* Inactive: not meeting the US resistance and aerobic exercise guidelines over the last 6 months
* Walking \<7,000 steps/day at baseline
* Capable of performing the required exercise training

Exclusion Criteria:

Absolute

* Unstable coronary heart disease or heart failure
* Uncontrolled arrhythmias or severe aortic stenosis
* Acute myocarditis, endocarditis, or pericarditis
* Cancer, requiring treatment in the past 5 years
* Autoimmune diseases, affecting immune system
* Plans to be away ≥4 weeks in the next 1 year
* Pregnancy/anticipated pregnancy during the study
* Other medical condition that is life-threatening or can interfere with or be aggravated by the exercise training
* Uncontrolled Diabetes (HbA1c ≥8.0),
* Hypertensive Blood Pressure ≥160 mm Hg Systolic and/or 100 mm Hg Diastolic,

Relative (should consult a physician)

* Major risk factors for coronary heart disease
* Uncontrolled diabetes or musculoskeletal limitations

Where it's running

• Physical Activity Research Center (PARC)
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Duck-chul Lee, PhD — University of Pittsburgh
• Study coordinator: Duck-chul Lee, PhD
• Email: dclee@pitt.edu
• Phone: 412-383-4004

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.