Kaempferol absorption and pharmacokinetics in healthy adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multi-site interventional study gives a controlled oral dose of kaempferol to healthy adult volunteers and collects serial blood and urine samples over a short period. Samples are processed using harmonized procedures at each site and analyzed centrally to define pharmacokinetic parameters and bioavailability. Selected biospecimens will undergo molecular profiling to explore changes linked to kaempferol exposure, including markers related to metabolism and mitochondrial function. The overall goal is to generate standardized human data to inform dosing, safety, and future translational or regulatory planning.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Adults aged 18 to 70 years

* Healthy volunteers as determined by medical history and screening assessment
* Ability to understand the study procedures and provide informed consent
* Willingness and ability to comply with all study procedures, including dietary restrictions, clinic visits, blood draws, urine collection, and follow-up assessments
* Willingness to abstain from restricted foods, beverages, and supplements as specified in the study protocol during the study period

Exclusion Criteria:

* Known allergy or hypersensitivity to Kaempferol or related flavonoids
* Pregnancy or breastfeeding
* Presence of significant acute or chronic medical conditions that could increase risk or interfere with study outcomes, including but not limited to:
* Active or chronic infections
* Cancer
* Cardiovascular disease
* Neurological or neurodegenerative disorders
* Metabolic or systemic inflammatory conditions
* Use of prescription medications or supplements known to interfere with Kaempferol metabolism or pharmacokinetic assessment
* Blood donation within 8 weeks prior to study enrollment
* Participation in another interventional clinical study within a timeframe that could interfere with study results or participant safety
* Any condition or circumstance that, in the judgment of the study investigator, would make participation unsafe or compromise data integrity

Where it's running

• University of Pittsburgh
  Pittsburgh, Pennsylvania, United States Recruiting
• Weill Cornell Medicine
  New York, New York, United States Not yet recruiting
• University of North Carolina at Chapel Hill
  Chapel Hill, North Carolina, United States Not yet recruiting

Study contacts

• Principal investigator: Afshin Beheshti, PhD — University of Pittsburgh
• Study coordinator: Afshin Beheshti, PhD
• Email: beheshti@pitt.edu
• Phone: 6173082540

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.