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Impact of Parenthood on Health in People with Cystic Fibrosis

Health Outcomes of Parents With Cystic Fibrosis-Aim 2

Observational University of Pittsburgh · NCT06296394

This study looks at how becoming a parent affects the health of people with cystic fibrosis, especially their lung function and mental well-being, over five years.

Quick facts

Study typeObservational
Enrollment146 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Pittsburgh Academic / other
Locations18 sites (Birmingham, Alabama and 17 other locations)
Trial IDNCT06296394 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate the health effects of parenthood on individuals with cystic fibrosis (CF) in the context of modern CFTR modulator therapies. It will follow 146 new parents of children under 5 years old across 18 CF centers in the US, assessing both physical and mental health outcomes over a period of up to 5 years. The study will investigate how factors such as depression and parental responsibilities influence lung function, measured by percent predicted forced expiratory volume in one second (ppFEV1). Additionally, qualitative interviews will be conducted to gather insights on the psychosocial impacts of parenthood and identify potential areas for intervention.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals diagnosed with cystic fibrosis who have recently become first-time parents to a child under 5 years of age.

Not a fit: Patients who have undergone a lung transplant or do not speak/read English or Spanish may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into how parenthood affects the health of individuals with cystic fibrosis, potentially leading to targeted interventions that improve their quality of life.

How similar studies have performed: While this study explores a relatively novel area of research, similar studies have shown the importance of psychosocial factors in chronic illness management, indicating potential for meaningful findings.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Diagnosed with cystic fibrosis via sweat test or genotype analysis
* Became a first-time parent (including foster parent, step parent, adoptive parent, or legal guardian) to a child under 5 years of age within the last 180 days

Exclusion Criteria:

* Undergone a lung transplant
* Does not speak/read English or Spanish

Where this trial is running

Birmingham, Alabama and 17 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cystic FibrosisParenthood Statuscystic fibrosisparenthoodhighly effective modulator therapy
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.