Comparing Clopidogrel and Aspirin after Stent Implantation for Heart Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of clopidogrel monotherapy versus aspirin monotherapy following a short-term dual antiplatelet therapy (DAPT) in patients with ischemic heart disease who have undergone percutaneous coronary intervention (PCI) with zotarolimus-eluting stents. Patients will be randomized to receive either clopidogrel or aspirin after a 1- to 3-month DAPT period, with stratification based on bleeding risk, clinical presentation, and lesion complexity. The primary outcome is the rate of net adverse clinical events (NACE) at 12 months post-PCI. This study aims to determine which antiplatelet agent is more beneficial for patients after short-term DAPT.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients ≥19 years
2. Patients who received new generation zotarolimus-eluting Onyx stents implantation for treating ischemic heart disease
3. Provision of informed consent

Exclusion Criteria:

1. Age ≥ 85 years
2. Acute myocardial infarction

2\. Left main bifurcation requiring 2-stent technique 3. Pregnant women or women with potential childbearing 4. Life expectancy \< 1 year 5. Inability to follow the patient over the period of 1 year after enrollment, as assessed by the investigator 6. Inability to understand or read the informed consent

Where it's running

• Yonsei University Health System, Severance Hospital
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Byeong-Keuk Kim — Severance Cardiovascular Hospital, Yonsei University Health System
• Study coordinator: Byeong-Keuk Kim
• Email: kimbk@yuhs.ac
• Phone: 82-2228-8460

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.