Evaluating heart muscle viability in patients with ischemic heart disease using advanced imaging techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the effectiveness of integrated 18F-FDG PET/MR imaging in detecting viable heart muscle in patients with ischemic heart disease. It compares this method to the traditional combination of 18F-FDG PET and 99mTc MIBI SPECT/CT imaging to determine if the newer approach can serve as a replacement. The study will involve evaluating coronary artery stenosis, myocardial ischemia, and survival status prior to surgical interventions, which is crucial for optimizing treatment plans. The goal is to ensure that only patients with viable myocardium undergo revascularization procedures, thereby improving outcomes and reducing surgical risks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults under the age of 80
2. Coronary angiography shows coronary artery disease, with at least 2 coronary arteries having a degree of stenosis greater than 80%
3. ft ventricular ejection fraction (LVEF)\<40%
4. Acute myocardial infarction onset for at least 3 months
5. Patients with old myocardial infarction with no acute coronary artery events in the past 3 months
6. Patients of pre implementation of coronary artery bypass grafting (CABG) or combined treatment with human umbilical cord mesenchymal stem cells (iPSC)
7. Agree to participate in this clinical trial and sign an informed consent form
8. Good compliance

Exclusion Criteria:

* 1.Patients with diabetes or other patients with poor blood glucose control (fasting blood glucose value on the test day is greater than 10mmol/L) 2.Patients who allergy to MR contrast agent 3.Electronic implants such as pacemakers, nerve stimulators, insulin pumps, cochlear implants 4.Patients who have undergone aneurysm surgery and have intracranial aneurysm clips 5.Patients who have undergone heart surgery and have an artificial heart valve 6.Patients with metal foreign objects in the eyes 7.Patients with metal implants and prostheses, or metal foreign bodies in other parts of body 8.Severe liver and kidney dysfunction 9.Accompanied by arrhythmia such as atrial fibrillation, cerebrovascular disease, and severe pulmonary heart disease 10.Pregnant or plan to pregnant within three months or lactating women 11.Critically ill patients who require the use of life support systems 12.Patients with claustrophobia 13.Other situations which clinical trial personnel deem it inappropriate to participate in this trial

Where it's running

• Shanghai East Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Jun Zhao, Professor
• Email: petcenter@126.com
• Phone: 13816137450

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.