Comparing radiofrequency ablation to implantable defibrillator for ventricular tachycardia in heart disease patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of radiofrequency ablation versus implantable defibrillators in patients with ischemic heart disease who experience well-tolerated ventricular tachycardia and have minimally impaired left ventricular ejection fraction. The study will collect data on adverse events, assess quality of life using the EQ-5D-5L questionnaire, and perform a medical-economic evaluation. The goal is to determine if ablation can reduce mortality and recurrence rates in this specific patient population, which has not been extensively studied before.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ischemic heart disease with history of infarction - LVEF\> 35% (measured by MRI)
* sustained monomorphic ventricular tachycardia - without history of syncope or cardiac arrest -
* having signed informed consent
* affiliated to a social security system

Exclusion Criteria:

* transient regressive cause of ventricular tachycardia
* recent myocardial infarction (\<2 months)
* ventricular tachycardia by reentry from branch to branch
* serious conduction disturbances (with indication of stimulation)
* contraindication to the implantation of a defibrillator or to the performance of an ablation (life expectancy \<1 year, relevant comorbidities)
* pregnancy
* age \<18 years
* Patient under legal protection, guardianship or curatorship

Where it's running

• Rangueil Hospital
  Toulouse, France, France Recruiting

Study contacts

• Principal investigator: Philippe MAURY, MD — University Hospital, Toulouse
• Study coordinator: Philippe MAURY, MD
• Email: maury.p@chu-toulouse.fr
• Phone: 5 61 34 10 18

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.