Endothelial Fli1 and heart disease in ischemia
Official title: Endothelial Fli1 In Ischemic Heart Disease
Funded at Ut Southwestern Medical Center · NIH-11365606 · Data updated 2026-11-12
A study in people with heart disease clues how a blood-vessel gene, Fli1, helps protect the heart during a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $718,548 |
| NIH project number | 1R01HL180354-01A1 |
| Project ID | NIH-11365606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with ischemic heart disease or heart failure who could benefit from therapies targeting blood vessel, immune, or heart muscle cell interactions in the setting of reduced blood flow.
✕Less likely to help
Individuals without ischemic heart disease or those not at risk for heart attack-related heart injury may not benefit from this research.
What this research studies
This project looks at how the Fli1 gene in the inner lining of blood vessels affects heart damage after ischemia. Researchers will use mouse models with controlled Fli1 activity and study changes when the heart is stressed by reduced blood flow, aiming to uncover how endothelial Fli1 supports heart cell communication and repair. The work could reveal new ways to protect the heart from injury and improve recovery after a heart attack, potentially guiding future therapies. The team plans to connect vascular signals to immune and heart muscle cell responses to promote healing.
Why it matters
Potential benefit: If successful, this research could lead to new targets for protecting the heart after a heart attack and improve outcomes for patients with ischemic heart disease.
How similar studies have gone: Previous work shows endothelial signals can influence heart repair, but this specific Fli1 pathway in humans is still being explored.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Hill, Joseph a — Ut Southwestern Medical Center
- Study coordinator: Hill, Joseph a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.