Comparing two methods for diagnosing heart conditions in patients with non-ST elevation acute coronary syndrome
Official title: Team-based Interventional Triage in Acute Coronary Syndrome Based on Non-Invasive Computed Tomography Coronary Angiography - a Randomized Trial
Run by Copenhagen University Hospital, Rigshospitalet · NCT06101862 · Data updated 2026-11-12
This study is testing if a non-invasive heart scan can safely and effectively diagnose heart conditions in patients with certain types of heart attacks, compared to the traditional invasive method.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 2300 (estimated) |
| Sponsor | Copenhagen University Hospital, Rigshospitalet Academic / other |
| Locations | 6 sites (Copenhagen, Hellerup and 5 other locations) |
| Status | Recruiting |
| Started | October 1, 2023 |
| Main results expected | October 1, 2026 |
| Study ends | October 1, 2036 |
| Registry record updated | February 19, 2025 |
| Trial ID | NCT06101862 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals admitted with non-ST-segment elevation myocardial infarction or unstable angina who require subacute invasive coronary angiography.
✕Probably not a fit
Patients who are unstable and require immediate invasive coronary angiography or those with severe comorbidities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of coronary computed tomography angiography (CCTA) compared to invasive coronary angiography (ICA) in patients diagnosed with non-ST-segment elevation myocardial infarction (NSTEACS). It aims to determine if CCTA can serve as a safer and more efficient alternative to ICA, which is traditionally used in acute settings. The trial will involve patients who meet specific criteria, including those with elevated troponin levels or ischemic changes on their electrocardiograms. By assessing the outcomes of both diagnostic methods, the study seeks to provide evidence that could influence clinical practice in acute coronary syndrome management.
Why it matters
Potential benefit: If successful, this study could lead to a safer and more comfortable diagnostic approach for patients with acute coronary syndrome, reducing complications and healthcare costs.
How similar studies have gone: While CCTA is widely accepted for chronic conditions, this study is novel as it specifically investigates its use in the acute setting for NSTEACS, with limited prior large-scale randomized trials available.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Admitted with non-ST-segment elevation myocardial infarction or unstable angina pectoris and an indication for subacute ICA * Elevated troponin or ischemic electrocardiographic changes * Written informed consent Exclusion criteria: * Instability requiring acute or emergent ICA * History of percutaneous coronary intervention or coronary artery bypass grafting * Estimated glomerular filtration rate \< 30 mL/min/1.73m2 * Probable type 2 acute myocardial infarction * Severe valvular heart disease as primary diagnosis or potential need for valve intervention * History of spontaneous coronary artery dissection * Expected poor quality of the CCTA * Prior CCTA or ICA during index admission or within 1 week * Known allergy to beta-blockers or contrast agent * Pregnant or nursing * Previously randomized in this trial
Where it's running
-
Herlev and Gentofte Hospital
Copenhagen, Hellerup, Denmark Recruiting -
Bispebjerg Hospital
Bispebjerg, Denmark Recruiting -
Rigshospitalet
Copenhagen, Denmark Recruiting -
Zealand University Hospital
Copenhagen, Denmark Recruiting -
North Zealand Hospital
Hillerød, Denmark Recruiting -
Hvidovre Hospital
Hvidovre, Denmark Recruiting
Study contacts
- Study coordinator: Niels Thue Olsen, PhD
- Email: niels.thue.olsen@regionh.dk
- Phone: +45 38 68 38 68
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.