Understanding brain and heart injuries after bleeding in the brain

Multimodal Omics and Imaging Study on the Mechanisms of Brain-heart Injury in Patients With Intracranial Hemorrhage

This study looks at how bleeding in the brain affects both the brain and the heart in adults to better understand the connection between these injuries.

Quick facts

• Study type: Observational
• Enrollment: 1000 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Beijing Tiantan Hospital (other)
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT06906432 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate the mechanisms of brain and heart injuries that occur following an intracranial hemorrhage, particularly focusing on the cerebrocardiac syndrome. Patients aged 18 and older with confirmed acute intracranial hemorrhage will be enrolled and undergo a multi-disciplinary assessment to evaluate both cerebral and cardiac complications. The study seeks to clarify the pathophysiological processes involved and their implications for diagnosis and treatment strategies. By analyzing these mechanisms, the research hopes to enhance understanding of the relationship between brain injuries and cardiac complications.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who have experienced an acute intracranial hemorrhage confirmed by neuroimaging within 48 hours of symptom onset.

Not a fit: Patients with significant pre-existing cardiovascular diseases or those who have undergone recent cardiovascular interventions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for patients suffering from brain injuries and associated cardiac complications.

How similar studies have performed: While the specific mechanisms of brain-heart injury in this context are not extensively studied, related research on cerebrocardiac syndrome has shown promising insights into the connections between brain injuries and cardiac complications.

Eligibility criteria

Inclusion Criteria:

1. Patients aged 18 years or older at the time of enrollment.
2. Acute intracranial hemorrhage confirmed by neuroimaging (CT, MRI，CTA, MRA, or DSA) within 48 hours of symptom onset.
3. Ability to provide informed consent or have a legally authorized representative willing to consent on their behalf.

Exclusion Criteria:

1. Patients who refuse to participate in the study or cannot provide informed consent.
2. Patients with a history of significant cardiovascular disease, including myocardial infarction, heart failure, or arrhythmias, unless stable and well-controlled.
3. Patients who have undergone cardiac bypass surgery, stent placement, or other cardiovascular interventions within the past 6 months.
4. Patients with active brain tumors, ischemic stroke within 3 months or a history of previous brain injury that could confound the study findings.
5. Patients with active malignant disease, severe inflammatory or infectious disease, or those who have undergone surgery for any reason within the past 3 months.
6. Patients with any condition that, in the opinion of the investigator, would make it unsafe or impractical to participate in the study.

Where this trial is running

Beijing, Beijing Municipality

• Beijing Tiantan Hospital Affiliated to Capital Medical University — Beijing, Beijing Municipality, China (RECRUITING)

Conditions: Subarachnoid Hemorrhage, Aneurysmal, Cerebrocardiac Syndrome, Mass Spectrometry, Heart Failure, Atrial Fibrillation, Ischemic Heart Disease, Heart Infarction, Arrhythmias, Cardiac