Hyperpolarized MRSI in Ischemic Heart Disease: A Metabolic Investigation of the Heart Muscle

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

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Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic heart failure
* \>18 years of age
* Left ventricular Ejection Fraction (LVEF) of 10 - 60 %
* Adequate hematologic and organ function.
* Women who are not postmenopausal or surgically sterile must have a negative serum or urine pregnancy test performed at time of inclusion in the study.
* Safe and highly effective contraception must be used throughout the study meaning either hormonal anti-conception or an anti-fertility intrauterine device. If the partner is non fertile or the patient has no sexual activities, this is also accepted.
* Non-insulin dependent Diabetes mellitus is allowed
* Danish speaking
* Able and willing to comply after informed consent
* Ischemic heart disease and referral to viability testing at the Department of Clinical Physiology and Nuclear Medicine at Aarhus University Hospital.

Exclusion Criteria:

* Not able or willing to receive heart failure therapy
* Patients not willing to participate
* Uncontrolled serious medical condition, such as uncontrolled heart disease, uncontrolled diabetes, intestinal obstruction, uncontrolled hypertension, or recent cerebral ischemia
* Estimated Glomerular Filtration Rate (eGFR) \<30 mL/min
* Insulin dependent Diabetes Mellitus
* Intolerance to Pyruvate

Where it's running

• Aarhus University Hospital
  Aarhus, Central Jutland, Denmark Recruiting

Study contacts

• Study coordinator: Niels A. Jespersen, MD
• Email: nijesp@rm.dk
• Phone: +4522950990

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.