QFR-guided virtual stenting to optimize PCI before the procedure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter trial compares virtual stenting-guided PCI optimization to conventional angiography-guided PCI. It uses imaging-physiology fusion to simulate post-PCI physiology and guide stent strategy before intervention. Eligible adults with coronary artery disease undergoing PCI are randomized 1:1 to receive either the virtual stenting approach or standard care. The primary endpoint is 1-year major adverse cardiovascular events. The study aims to determine if preprocedural physiological optimization can translate into better clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years.
* Diagnosis of coronary artery disease requiring percutaneous coronary intervention (PCI) according to current clinical practice.
* Presence of at least one target coronary lesion considered suitable for PCI and evaluable by angiography-derived Quantitative Flow Ratio (QFR).
* Ability to undergo coronary angiography and PCI. Provision of written informed consent before study participation.

Exclusion Criteria:

* Contraindications to PCI or inability to undergo coronary intervention. Severe renal dysfunction or other conditions making angiographic procedures unsuitable.
* High bleeding risk judged by investigators.
* Inability to complete follow-up or comply with study procedures.
* Life expectancy less than 1 year due to non-cardiovascular comorbidities.
* Participation in another interventional clinical trial that may interfere with study outcomes.
* Coronary anatomy unsuitable for QFR-based virtual stenting analysis.
* Any condition judged by investigators to make study participation inappropriate.

Where it's running

• Fuwai Hospital, CAMS & PUMC
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Ying Song, MD
• Email: songying@fuwai.com
• Phone: +86-10-68314466

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.