Condition

Dilated Cardiomyopathy clinical trials and research

• 16Clinical trials
• 36NIH research projects
• 11Countries

Newest Dilated Cardiomyopathy clinical trials

All recruiting trials (16)

• Natural history of BAG3-related dilated cardiomyopathy in Chinese adults

  This is an observational study in Chinese adults with BAG3-related dilated cardiomyopathy to describe how the disease progresses over time.

  Recruiting AstraZeneca · Beijing and 2 other locations · NCT07646600

• Monitoring progression of chronic cardiovascular conditions

  This project will collect wearable physiologic data from adults with cardiovascular conditions to see how their heart disease changes over time.

  Recruiting Prolaio · Chicago, Illinois · NCT07420907

• AZD4063 for PLN R14del dilated cardiomyopathy.

  This study will test whether AZD4063 is safe and how the body processes it in adults with PLN R14del dilated cardiomyopathy.

  Recruiting at 4 sites Phase 1 AstraZeneca · Amsterdam and 3 other locations · NCT07241104

• Identifying patients with cardiomyopathy for potential heart transplantation

  This study is trying to find new ways to identify and understand cardiomyopathy in patients to better predict if they might need a heart transplant in the future.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Emilia-Romagna/Bologna and 2 other locations · NCT06813443

• Predicting Ventricular Tachycardia Events in Patients with Non-Ischemic Cardiomyopathy

  This study is trying to see if certain heart imaging tests can help predict the risk of dangerous heart rhythms and sudden cardiac death in people with non-ischemic cardiomyopathy.

  Recruiting at 4 sites Centro Medico Teknon · Milan, Italy and 3 other locations · NCT06730464

• AI-based assessment of heart function using ECG wearable monitors

  This study tests if a new AI tool using a wearable heart monitor can accurately check heart function in people with heart failure compared to traditional heart scans.

  Recruiting at 8 sites Peerbridge Health, Inc · Orange, California and 7 other locations · NCT06699056

• Using AI and mobile technology to screen for dilated cardiomyopathy in family members

  This study is testing if using a special mobile EKG device can help family members of people with dilated cardiomyopathy get screened for heart problems more often.

  Recruiting Lancaster General Hospital · Lancaster, Pennsylvania · NCT06688396

• IV donor neonatal mesenchymal stromal cells for dilated cardiomyopathy in children and young adults

  We will test whether IV infusions of donor neonatal mesenchymal stromal cells can safely improve heart pumping (left ventricular ejection fraction) in children and young adults with dilated cardiomyopathy.

  Recruiting at 5 sites Phase 1 Emory University · Atlanta, Georgia and 4 other locations · NCT06464588

• Bromocriptine treatment for women with dilated cardiomyopathy

  This study is testing if bromocriptine can help improve heart function in women aged 18 to 50 with dilated cardiomyopathy compared to standard treatments.

  Recruiting Phase 3 Jimma University · Jimma, Oromiya · NCT06250257

• Effects of Sirolimus on Heart Disease in Patients with a Specific Virus

  This study is testing if the drug sirolimus can help improve heart health in patients with dilated cardiomyopathy who are also infected with a specific virus.

  Recruiting Phase 4 Tongji Hospital · Wuhan, Hubei · NCT06236022

• Observing the causes and progression of cardiomyopathy

  This study is trying to understand what causes cardiomyopathy and how it gets worse by collecting DNA, blood samples, and health information from people with the condition or those at risk.

  Recruiting at 2 sites Imperial College London · London and 1 other locations · NCT05750147

• Coronary blood flow testing in people with reduced ejection fraction and left bundle branch block after CRT

  This work will test whether direct intracoronary measurements of flow and pressure show reduced coronary blood flow in people with low ejection fraction and left bundle branch block who have a CRT device.

  Recruiting Aalborg University Hospital · Aalborg · NCT05564689

• Using cardiac MRI to assess risk in patients with dilated cardiomyopathy

  This study is testing how cardiac MRI can help doctors understand the risks and better manage patients with dilated cardiomyopathy.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality · NCT04990297

• A quick 10-minute heart scan for cardiac diseases

  This study is testing a quick 10-minute heart scan to see if it can help diagnose heart problems better and faster for many patients without needing special dyes.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04464655

• Collecting biological samples and imaging data to study heart health and disease

  This study is collecting health information and samples from people with heart conditions and healthy volunteers to learn more about heart health and disease.

  Recruiting National Heart Centre Singapore · Singapore, Singapore · NCT02804269

• Analyzing genetic mutations in pediatric cardiomyopathy

  This study is trying to learn more about the genetic causes of heart problems in children with cardiomyopathy to help improve diagnosis and treatment options for them.

  Recruiting Indiana University · Indianapolis, Indiana · NCT02432092

NIH-funded research (36)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data

  A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11511735

• Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it

  This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11433394

• Unlocking how rare genetic changes cause dilated cardiomyopathy

  A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11420431

• Role of Lmod2 in heart muscle and dilated cardiomyopathy

  This NIH grant explores how a heart-specific protein (Lmod2) helps heart cells contract properly and how its problems can cause dilated cardiomyopathy in infants and children.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11395217

• Targeting DNA Damage Pathways in LMNA-Related Heart Disease

  A study to understand how damaged DNA and inflammatory signals contribute to dilated cardiomyopathy caused by LMNA mutations and explore therapies that can protect the heart.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11394336

• Using miRNA to find new treatment paths for dilated cardiomyopathy

  Researchers are studying heart-muscle disease (dilated cardiomyopathy) to discover miRNA-based clues that could lead to targeted therapies for patients.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11381812

• Skeletal muscle actin mutations and heart disease: understanding how a specific mutation affects heart function

  A physician-scientist at Johns Hopkins is studying how a skeletal muscle protein mutation (ACTA1 R256H) affects heart muscle function to help people with dilated cardiomyopathy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11364131

• Targeting immune and fibroblast crosstalk in genetic dilated cardiomyopathy

  A patient-focused program aims to understand how inflammation and fibroblasts interact in genetic dilated cardiomyopathy to identify new ways to slow or stop damaging heart remodeling.

  NIH research Stanford University · Stanford, United States · NIH-11339410

• N-terminal acetylation and heart disease in people with autism spectrum traits

  This grant looks at how a specific protein modification may contribute to heart problems in people with autism, aiming to uncover targets that could reduce dangerous heart rhythms.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11330165

• CRI-103 gene therapy for dilated cardiomyopathy

  A new gene therapy called CRI-103 aims to help adults with dilated cardiomyopathy by blocking a key heart-regulating protein interaction to prevent harmful heart remodeling.

  NIH research Cardiac Rsk3 Inhibitors, LLC · Los Altos, United States · NIH-11292808

• Finding why sudden cardiac death happens in dilated cardiomyopathy and how to stop it

  Looks at whether genetics and heart scarring can predict and help prevent deadly heart rhythms in people with dilated cardiomyopathy.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11292375

• Understanding familial dilated cardiomyopathy to guide personalized treatments

  This project will try boosting a stress-response protein called ATF4 to improve heart muscle function in people with inherited dilated cardiomyopathy.

  NIH research Stanford University · Stanford, United States · NIH-11258530

• How dilated cardiomyopathy mutations change heart muscle myosin

  Researchers will look at how inherited gene changes that cause dilated cardiomyopathy alter the structure and function of the heart’s myosin motor in people with inherited DCM.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11235942

• Using microRNA to help hearts affected by dilated cardiomyopathy

  They are trying small RNA molecules to help heart muscle cells work better in people with inherited dilated cardiomyopathy.

  NIH research Stanford University · Stanford, United States · NIH-11235201

• Understanding Lmod2's role in heart muscle and dilated cardiomyopathy

  This project looks at how problems with the Lmod2 protein harm heart muscle in people with dilated cardiomyopathy and explores ways to restore its function.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11227167

• Understanding how microRNAs affect heart function in dilated cardiomyopathy

  This study is looking at tiny molecules called microRNAs to see how they can help improve heart function in people with dilated cardiomyopathy, a condition that can lead to heart failure, by finding new ways to treat the genetic issues behind it.

  NIH research Stanford University · Stanford, United States · NIH-11223478

• Understanding the causes of familial dilated cardiomyopathy to improve treatment options

  This study is looking at a heart condition called familial dilated cardiomyopathy (DCM) and is testing how a protein called ATF4 can help improve heart function, with the hope of finding new treatments for people with DCM, no matter what genetic changes they have.

  NIH research Stanford University · Stanford, United States · NIH-11212025

• How mutations in heart muscle proteins affect heart function

  This study is looking at how certain genetic changes linked to dilated cardiomyopathy (DCM) affect a vital heart protein, which could help us understand heart failure better and find new treatments for people with DCM.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11211185

• DNA damage and treatments for LMNA-related dilated cardiomyopathy

  This project looks at how DNA damage causes heart weakening in people with LMNA gene mutations and tests whether blocking DNA-sensing pathways can protect the heart.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11174304

• miRNA-guided approaches to find new treatments for dilated cardiomyopathy

  This project looks at tiny RNA molecules in lab-grown human heart cells to find new treatment targets for people with dilated cardiomyopathy.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11164745

• Understanding heart muscle weakness from a protein defect

  This work explores how a specific protein defect in heart muscle cells contributes to a common form of inherited heart weakness called dilated cardiomyopathy.

  NIH research University of Washington · Seattle, United States · NIH-11163432

• Identifying new treatments for dilated cardiomyopathy using microRNA

  This study is looking at how tiny molecules called microRNAs affect dilated cardiomyopathy, a heart condition that can lead to heart failure, to find new ways to help people with this disease feel better.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11127039

• Understanding Cell Communication in Inherited Dilated Cardiomyopathy

  This research explores how heart cells communicate with each other in an inherited heart condition called dilated cardiomyopathy, using special human cells.

  NIH research Stanford University · Stanford, United States · NIH-11110408

• Understanding how N-terminal acetylation affects heart function and arrhythmias

  This study is looking at how certain genetic changes affect heart function in people with dilated cardiomyopathy and arrhythmias, using special cells from patients to better understand these conditions and find new ways to help treat them.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11083117

• Understanding how myosin affects heart function in dilated cardiomyopathy

  This study is looking into how certain proteins in your heart muscle work and how we can change their activity to help improve heart function for people with dilated cardiomyopathy.

  NIH research University of Kentucky · Lexington, United States · NIH-11074049

• Understanding the causes of sudden cardiac death in patients with dilated cardiomyopathy.

  This study is looking at how certain genetic factors and heart changes can help doctors find out which patients with dilated cardiomyopathy are at risk for serious heart problems, so they can create better treatments and prevention plans for them.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11047759

• Finding ways to increase titin protein levels to treat heart disease.

  This study is looking at how changes in a specific gene can affect heart health in people with dilated cardiomyopathy, and they're using human stem cells to find ways to boost a protein that helps the heart work better, with the hope of discovering new treatments to keep hearts strong and healthy.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11047743

• Understanding how genetic factors cause familial dilated cardiomyopathy to improve treatment options

  This study is looking at a heart condition called familial dilated cardiomyopathy (DCM) and how a protein named ATF4 might help heart cells handle stress better, with the hope that boosting this protein could lead to new treatments for patients with DCM, no matter what genetic mutations they have.

  NIH research Stanford University · Stanford, United States · NIH-11016931

• Understanding how microRNAs affect heart function in dilated cardiomyopathy

  This study is looking at tiny molecules called microRNAs to see how they can help improve heart function in people with dilated cardiomyopathy, a condition that can lead to heart failure, by finding new ways to target specific genes that cause this issue.

  NIH research Stanford University · Stanford, United States · NIH-11000356

• Understanding how protein stress affects heart function in genetic heart disease

  This study is looking at how a specific stress response in heart cells might help people with Genetic Dilated Cardiomyopathy (DCM) feel better, by using heart cells made from patients' own stem cells to see how they react to problems caused by misfolded proteins.

  NIH research Stanford University · Stanford, United States · NIH-10998462

• How mutations in heart muscle proteins affect heart function

  This study looks at how certain genetic changes linked to dilated cardiomyopathy (DCM) affect a key protein in your heart that helps it pump blood, with the goal of finding out more about heart failure and helping develop better treatments for patients like you.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10983294

• Assessing genetic risk factors for dilated cardiomyopathy

  This study is looking at how our genes might affect the risk of developing dilated cardiomyopathy, a serious heart condition, so that patients can get better screening and personalized treatments based on their genetic makeup.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10910905

• Using cardiac imaging to identify early signs of heart disease in families at risk

  This study is looking at how special heart scans can spot early signs of dilated cardiomyopathy in family members of people who have the condition, helping to catch any changes in the heart before symptoms appear.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10895268

• Understanding heart disease caused by faulty protein signaling

  This study is looking at how problems with a protein called Filamin C affect heart function in people with dilated cardiomyopathy (DCM), with the hope of finding better ways to diagnose and treat this heart condition.

  NIH research University of Washington · Seattle, United States · NIH-10894897

• Investigating how mutations in skeletal muscle actin affect heart function in dilated cardiomyopathy

  This study is looking at how a specific change in a muscle protein might affect heart function in people with dilated cardiomyopathy, with the hope of finding better treatments for those living with this condition.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10863630

• Understanding heart mechanics in patients with dilated cardiomyopathy

  This study is looking at how we can better understand heart function in people with dilated cardiomyopathy (DCM) by using special ultrasound techniques, especially for those who might be at risk due to their genes, so we can catch any early signs of heart issues and tailor treatments just for them.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10436899

Related topics

Quick answers

How many Dilated Cardiomyopathy clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (5 trials), China (3 trials), Italy (2 trials), Denmark (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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