Understanding how heart lymphatics help repair damage after heart attacks
Official title: Dissecting the functional roles of cardiac lymphatics in ischemic heart disease
Funded at Temple Univ of the Commonwealth · NIH-11003752 · Data updated 2026-11-12
This study is looking at how boosting the growth of lymphatic vessels in the heart after a heart attack can help improve heart function and speed up healing by reducing inflammation, and it's designed for anyone interested in new ways to support heart recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 13, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $423,274 |
| NIH project number | 5R01HL163269-03 |
| Project ID | NIH-11003752 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a myocardial infarction or are at risk for ischemic heart disease.
✕Less likely to help
Patients with non-cardiac related conditions or those who have not experienced heart-related issues may not benefit from this research.
What this research studies
This research investigates the role of lymphatic growth in the heart following ischemic events, such as heart attacks. It aims to understand how stimulating lymphatic growth can improve heart function and aid in the healing process by clearing inflammation. The study will utilize various animal models to explore the molecular pathways involved in lymphatic function and its impact on heart muscle cell survival. By uncovering these mechanisms, the research seeks to identify new therapeutic targets for improving heart repair.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart recovery after heart attacks, potentially reducing morbidity and mortality.
How similar studies have gone: Previous studies have shown promising results in enhancing heart repair through lymphatic stimulation, indicating that this approach has potential for success.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Liu, Xiaolei — Temple Univ of the Commonwealth
- Study coordinator: Liu, Xiaolei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.